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Disruption of stromal hedgehog signaling initiates RNF5-mediated proteasomal degradation of PTEN and accelerates pancreatic tumor growth.
Pitarresi, Jason R; Liu, Xin; Avendano, Alex; Thies, Katie A; Sizemore, Gina M; Hammer, Anisha M; Hildreth, Blake E; Wang, David J; Steck, Sarah A; Donohue, Sydney; Cuitiño, Maria C; Kladney, Raleigh D; Mace, Thomas A; Chang, Jonathan J; Ennis, Christina S; Li, Huiqing; Reeves, Roger H; Blackshaw, Seth; Zhang, Jianying; Yu, Lianbo; Fernandez, Soledad A; Frankel, Wendy L; Bloomston, Mark; Rosol, Thomas J; Lesinski, Gregory B; Konieczny, Stephen F; Guttridge, Denis C; Rustgi, Anil K; Leone, Gustavo; Song, Jonathan W; Wu, Jinghai; Ostrowski, Michael C.
Afiliação
  • Pitarresi JR; Ohio State Biochemistry Graduate Program, The Ohio State University Columbus, Columbus, OH, USA.
  • Liu X; Division of Gastroenterology, Department of Medicine and Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.
  • Avendano A; Ohio State Biochemistry Graduate Program, The Ohio State University Columbus, Columbus, OH, USA.
  • Thies KA; Department of Surgery, Stanford University, Stanford, CA, USA.
  • Sizemore GM; Department of Mechanical and Aerospace Engineering and Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
  • Hammer AM; Hollings Cancer Center and Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, SC, USA.
  • Hildreth BE; Department of Radiation Oncology and Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
  • Wang DJ; Ohio State Biochemistry Graduate Program, The Ohio State University Columbus, Columbus, OH, USA.
  • Steck SA; Hollings Cancer Center and Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, SC, USA.
  • Donohue S; Hollings Cancer Center and the Darby Children's Research Institute, Medical University of South Carolina, Charleston, SC, USA.
  • Cuitiño MC; Department of Radiation Oncology and Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
  • Kladney RD; Cancer Biology & Genetics Department and Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
  • Mace TA; Hollings Cancer Center and Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, SC, USA.
  • Chang JJ; Ohio State Biochemistry Graduate Program, The Ohio State University Columbus, Columbus, OH, USA.
  • Ennis CS; Cancer Biology & Genetics Department and Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
  • Li H; Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
  • Reeves RH; Department of Mechanical and Aerospace Engineering and Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
  • Blackshaw S; Department of Mechanical and Aerospace Engineering and Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
  • Zhang J; Department of Physiology and McKusick-Nathans Institute for Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Yu L; Department of Physiology and McKusick-Nathans Institute for Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Fernandez SA; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Frankel WL; Department of Biomedical Informatics' and Center for Biostatistics, The Ohio State University, Columbus, OH, USA.
  • Bloomston M; Department of Biomedical Informatics' and Center for Biostatistics, The Ohio State University, Columbus, OH, USA.
  • Rosol TJ; Department of Biomedical Informatics' and Center for Biostatistics, The Ohio State University, Columbus, OH, USA.
  • Lesinski GB; Department of Pathology, The Ohio State University, Columbus, OH, USA.
  • Konieczny SF; Department of Surgery, The Ohio State University, Columbus, OH, USA.
  • Guttridge DC; Department of Biomedical Sciences, Ohio University, Athens, OH, USA.
  • Rustgi AK; Department of Hematology & Medical Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, USA.
  • Leone G; Department of Biological Sciences, Purdue Center for Cancer Research and Bindley Bioscience Center, Purdue University, West Lafayette, IN, USA.
  • Song JW; Ohio State Biochemistry Graduate Program, The Ohio State University Columbus, Columbus, OH, USA.
  • Wu J; Hollings Cancer Center and the Darby Children's Research Institute, Medical University of South Carolina, Charleston, SC, USA.
  • Ostrowski MC; Division of Gastroenterology, Department of Medicine and Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.
Life Sci Alliance ; 1(5): e201800190, 2018 Oct.
Article em En | MEDLINE | ID: mdl-30456390
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2018 Tipo de documento: Article