Synergistic effects of fast-neutron dose per epithermal neutron and 10B concentration on relative-biological-effectiveness dose for accelerator-based boron neutron capture therapy.
Appl Radiat Isot
; 144: 1-4, 2019 Feb.
Article
em En
| MEDLINE
| ID: mdl-30465991
ABSTRACT
The efficacy of accelerator-based boron neutron capture therapy was examined through relative-biological-effectiveness dose calculations with the fast-neutron dose per epithermal neutron (FNR) and the 10B concentration as parameters. In the case of a tumor 10B concentration of 65â¯ppm, the treatment efficacy depended more strongly on the FNR when the normal-tissue 10B concentration was 0.65â¯ppm, which would be brought about by the administration of an advanced chemical compound, than when the 10B concentration was 18â¯ppm, which is attainable by the use of boronophenylalanine.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Dosagem Radioterapêutica
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Eficiência Biológica Relativa
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Terapia por Captura de Nêutron de Boro
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Nêutrons Rápidos
Tipo de estudo:
Health_economic_evaluation
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article