Synergistic effects of fast-neutron dose per epithermal neutron and 10B concentration on relative-biological-effectiveness dose for accelerator-based boron neutron capture therapy.

ABSTRACT

The efficacy of accelerator-based boron neutron capture therapy was examined through relative-biological-effectiveness dose calculations with the fast-neutron dose per epithermal neutron (FNR) and the 10B concentration as parameters. In the case of a tumor 10B concentration of 65 ppm, the treatment efficacy depended more strongly on the FNR when the normal-tissue 10B concentration was 0.65 ppm, which would be brought about by the administration of an advanced chemical compound, than when the 10B concentration was 18 ppm, which is attainable by the use of boronophenylalanine.