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CD99 expression is strongly associated with clinical outcome in children with B-cell precursor acute lymphoblastic leukaemia.
Chen, Dongfeng; Camponeschi, Alessandro; Wu, Qingqing; Gerasimcik, Natalija; Li, Huiqi; Shen, Xue; Tan, Yujie; Sjögren, Helene; Nordlund, Jessica; Lönnerholm, Gudmar; Abrahamsson, Jonas; Fogelstrand, Linda; Mårtensson, Inga-Lill.
Afiliação
  • Chen D; Department of Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden.
  • Camponeschi A; Institute of Life Sciences, Jiangsu University, Zhenjiang, China.
  • Wu Q; Department of Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden.
  • Gerasimcik N; The Central Laboratory, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.
  • Li H; Department of Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden.
  • Shen X; Department of Occupational and Environmental Medicine, University of Gothenburg, Gothenburg, Sweden.
  • Tan Y; The Central Laboratory, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.
  • Sjögren H; The Central Laboratory, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.
  • Nordlund J; Department of Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden.
  • Lönnerholm G; Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
  • Abrahamsson J; Department of Women and Children's health, Uppsala University, Uppsala, Sweden.
  • Fogelstrand L; Department of Paediatrics, Institution of Clinical Sciences, Sahlgrenska University Hospital, Gothenburg, Sweden.
  • Mårtensson IL; Department of Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden.
Br J Haematol ; 184(3): 418-423, 2019 02.
Article em En | MEDLINE | ID: mdl-30484860
ABSTRACT
Our study aimed to determine the expression pattern and clinical relevance of CD99 in paediatric B-cell precursor acute lymphoblastic leukaemia (BCP-ALL). Our findings demonstrate that high expression levels of CD99 are mainly found in high-risk BCP-ALL, e.g. BCR-ABL1 and CRLF2Re/Hi, and that high CD99 mRNA levels are strongly associated with a high frequency of relapse, high proportion of positive for minimal residual disease at day 29 and poor overall survival in paediatric cohorts, which indicate that CD99 is a potential biomarker for BCP-ALL.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia-Linfoma Linfoblástico de Células Precursoras B / Biomarcadores Tumorais / Regulação Leucêmica da Expressão Gênica / Antígeno 12E7 Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia-Linfoma Linfoblástico de Células Precursoras B / Biomarcadores Tumorais / Regulação Leucêmica da Expressão Gênica / Antígeno 12E7 Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article