Evaluation of immune status in pediatric recipients of hepatic orthografts.
J Pediatr Surg
; 23(9): 825-8, 1988 Sep.
Article
em En
| MEDLINE
| ID: mdl-3054042
ABSTRACT
Survival in children following hepatic transplantation is better than in adults. We evaluated the immunologic status of both pediatric and adult patients prior to and following transplantation, to determine if there were differences in immunologic status that might contribute to this phenomenon. Studies included determination of mononuclear cell subsets, including T cells, T helper cells, T suppressor cells, and monocytes. In addition, we evaluated immune function by studying in vitro immunoglobulin (Ig) synthesis. Following transplantation, the T8 (cytotoxic/suppressor) cells in pediatric patients did not decline, whereas in adults they did (P less than .05). In vitro Ig synthesis in both adult and pediatric patients declined following transplantation. By 4 weeks, the adult group had begun to recover, whereas in the pediatric group there was still significant suppression (P less than .05). These studies suggest that there is decreased immune function in children who are recipients of hepatic allografts. Such findings could contribute to better outcome of hepatic allografting in children.
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Base de dados:
MEDLINE
Assunto principal:
Linfócitos
/
Transplante de Fígado
/
Contagem de Leucócitos
Limite:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Humans
/
Middle aged
Idioma:
En
Ano de publicação:
1988
Tipo de documento:
Article