M3Drop: dropout-based feature selection for scRNASeq.
Bioinformatics
; 35(16): 2865-2867, 2019 08 15.
Article
em En
| MEDLINE
| ID: mdl-30590489
ABSTRACT
MOTIVATION Most genomes contain thousands of genes, but for most functional responses, only a subset of those genes are relevant. To facilitate many single-cell RNASeq (scRNASeq) analyses the set of genes is often reduced through feature selection, i.e. by removing genes only subject to technical noise. RESULTS:
We present M3Drop, an R package that implements popular existing feature selection methods and two novel methods which take advantage of the prevalence of zeros (dropouts) in scRNASeq data to identify features. We show these new methods outperform existing methods on simulated and real datasets. AVAILABILITY AND IMPLEMENTATION M3Drop is freely available on github as an R package and is compatible with other popular scRNASeq tools https//github.com/tallulandrews/M3Drop. SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.
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Base de dados:
MEDLINE
Assunto principal:
Software
Tipo de estudo:
Risk_factors_studies
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article