Glutamyl-prolyl-tRNA synthetase induces fibrotic extracellular matrix via both transcriptional and translational mechanisms.

Song, Dae-Geun; Kim, Doyeun; Jung, Jae Woo; Nam, Seo Hee; Kim, Ji Eon; Kim, Hye-Jin; Kim, Jong Hyun; Lee, Seo-Jin; Pan, Cheol-Ho; Kim, Sunghoon; Lee, Jung Weon

Song, Dae-Geun; Kim, Doyeun; Jung, Jae Woo; Nam, Seo Hee; Kim, Ji Eon; Kim, Hye-Jin; Kim, Jong Hyun; Lee, Seo-Jin; Pan, Cheol-Ho; Kim, Sunghoon; Lee, Jung Weon.

Afiliação

Song DG; Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, South Korea.
Kim D; Systems Biotechnology Research Center, Korea Institute of Science and Technology (KIST), Gangneung-si, Republic of Korea.
Jung JW; Medicinal Bioconvergence Research Center, Seoul National University, Seoul, South Korea.
Nam SH; Interdisciplinary Program in Genetic Engineering, Seoul National University, Seoul, Republic of Korea; and.
Kim JE; Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, South Korea.
Kim HJ; Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, South Korea.
Kim JH; Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, South Korea.
Lee SJ; Medicinal Bioconvergence Research Center, Seoul National University, Seoul, South Korea.
Pan CH; Department of Life Science and Biotechnology, Shingyeong University, Gyeonggi-do, Republic of Korea.
Kim S; Systems Biotechnology Research Center, Korea Institute of Science and Technology (KIST), Gangneung-si, Republic of Korea.
Lee JW; Medicinal Bioconvergence Research Center, Seoul National University, Seoul, South Korea.

FASEB J ; 33(3): 4341-4354, 2019 03.

Article em En | MEDLINE | ID: mdl-30592630

Assuntos

Aminoacil-tRNA Sintetases/metabolismo; Matriz Extracelular/metabolismo; Biossíntese de Proteínas/genética; Transcrição Gênica/genética; Aminoacil-tRNA Sintetases/genética; Animais; Linhagem Celular; Colágeno Tipo I/genética; Colágeno Tipo I/metabolismo; Regulação para Baixo/genética; Matriz Extracelular/genética; Fibrose/genética; Fibrose/metabolismo; Células Estreladas do Fígado/metabolismo; Humanos; Fígado/metabolismo; Cirrose Hepática/genética; Cirrose Hepática/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Transdução de Sinais/genética; Fator de Crescimento Transformador beta1/genética; Fator de Crescimento Transformador beta1/metabolismo; Regulação para Cima/genética

Palavras-chave

STAT6; fibrotic animal model; hepatic stellate cells; prolyl-tRNA-synthetase; signal transduction

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transcrição Gênica / Biossíntese de Proteínas / Matriz Extracelular / Aminoacil-tRNA Sintetases Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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