Asymmetric Synthesis of the DEFG Rings of Solanoeclepin A.
Org Lett
; 21(3): 644-647, 2019 02 01.
Article
em En
| MEDLINE
| ID: mdl-30638387
ABSTRACT
Starting from ( R)-seudenol, an asymmetric synthesis of the DEFG rings of solanoeclepin A has been developed. The key transformations include the substrate-controlled asymmetric Staudinger ketene cycloaddition and the intramolecular aldol reaction leading to the tricyclo[5.2.1.01,6]decane core of solanoeclepin A in 10 steps in the longest reaction sequence.
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MEDLINE
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En
Ano de publicação:
2019
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Article