P53 ICE CRIM mouse: a tool to generate mutant allelic series in somatic cells and germ lines for cancer studies.

Fan, Hsiang-Hsuan; Yu, I-Shing; Lin, Yin-Hung; Wang, Shin-Yu; Liaw, Ying-Hsuan; Chen, Pei-Lung; Yang, Tsung-Lin; Lin, Shu-Wha; Chen, You-Tzung

Fan, Hsiang-Hsuan; Yu, I-Shing; Lin, Yin-Hung; Wang, Shin-Yu; Liaw, Ying-Hsuan; Chen, Pei-Lung; Yang, Tsung-Lin; Lin, Shu-Wha; Chen, You-Tzung.

Afiliação

Fan HH; Graduate Institute of Medical Genomics and Proteomics, College of Medicine, National Taiwan University, Taipei, Taiwan.
Yu IS; Laboratory Animal Center, College of Medicine, National Taiwan University, Taipei, Taiwan.
Lin YH; Graduate Institute of Medical Genomics and Proteomics, College of Medicine, National Taiwan University, Taipei, Taiwan.
Wang SY; Graduate Institute of Medical Genomics and Proteomics, College of Medicine, National Taiwan University, Taipei, Taiwan.
Liaw YH; Graduate Institute of Medical Genomics and Proteomics, College of Medicine, National Taiwan University, Taipei, Taiwan.
Chen PL; Graduate Institute of Medical Genomics and Proteomics, College of Medicine, National Taiwan University, Taipei, Taiwan.
Yang TL; Division of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan.
Lin SW; Department of Medical Genetics, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan.
Chen YT; Department of Otolaryngology, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan.

FASEB J ; 33(4): 5571-5584, 2019 04.

Article em En | MEDLINE | ID: mdl-30640520

Assuntos

Sistemas CRISPR-Cas/genética; Repetições Palindrômicas Curtas Agrupadas e Regularmente Espaçadas/genética; Mutação/genética; Neoplasias/genética; Proteína Supressora de Tumor p53/genética; Alelos; Animais; Edição de Genes/métodos; Marcação de Genes/métodos; Células Germinativas; Camundongos; Camundongos Transgênicos/genética; Mutagênese/genética; Oncogenes/genética; RNA Guia de Cinetoplastídeos/genética

Palavras-chave

genetic screen; genome editing; somatic mutagenesis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteína Supressora de Tumor p53 / Repetições Palindrômicas Curtas Agrupadas e Regularmente Espaçadas / Sistemas CRISPR-Cas / Mutação / Neoplasias Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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