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α-Synuclein O-GlcNAcylation alters aggregation and toxicity, revealing certain residues as potential inhibitors of Parkinson's disease.
Levine, Paul M; Galesic, Ana; Balana, Aaron T; Mahul-Mellier, Anne-Laure; Navarro, Mariana X; De Leon, Cesar A; Lashuel, Hilal A; Pratt, Matthew R.
Afiliação
  • Levine PM; Department of Chemistry, University of Southern California, Los Angeles, CA 90089.
  • Galesic A; Department of Chemistry, University of Southern California, Los Angeles, CA 90089.
  • Balana AT; Department of Chemistry, University of Southern California, Los Angeles, CA 90089.
  • Mahul-Mellier AL; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, School of Life Sciences, École Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.
  • Navarro MX; Department of Chemistry, University of Southern California, Los Angeles, CA 90089.
  • De Leon CA; Department of Chemistry, University of Southern California, Los Angeles, CA 90089.
  • Lashuel HA; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, School of Life Sciences, École Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.
  • Pratt MR; Department of Chemistry, University of Southern California, Los Angeles, CA 90089; matthew.pratt@usc.edu.
Proc Natl Acad Sci U S A ; 116(5): 1511-1519, 2019 01 29.
Article em En | MEDLINE | ID: mdl-30651314
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Acetilglucosamina / Acilação / Alfa-Sinucleína / Agregação Patológica de Proteínas Limite: Animals / Pregnancy Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Acetilglucosamina / Acilação / Alfa-Sinucleína / Agregação Patológica de Proteínas Limite: Animals / Pregnancy Idioma: En Ano de publicação: 2019 Tipo de documento: Article