Repression of hepatocyte nuclear factor 4 alpha by AP-1 underlies dyslipidemia associated with retinoic acid.

Won, Kyoung-Jae; Park, Joo-Seop; Jeong, Hyunyoung

Won, Kyoung-Jae; Park, Joo-Seop; Jeong, Hyunyoung.

Afiliação

Won KJ; Departments of Pharmacy Practice College of Pharmacy, University of Illinois at Chicago, Chicago, IL.
Park JS; Divisions of Pediatric Urology Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH; Developmental Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH.
Jeong H; Departments of Pharmacy Practice College of Pharmacy, University of Illinois at Chicago, Chicago, IL; Biopharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL. Electronic address: yjeong@uic.edu.

J Lipid Res ; 60(4): 794-804, 2019 04.

Article em En | MEDLINE | ID: mdl-30709899

Assuntos

Colesterol 7-alfa-Hidroxilase/metabolismo; Fator 4 Nuclear de Hepatócito/antagonistas & inibidores; Fator de Transcrição AP-1/metabolismo; Tretinoína/farmacologia; Células Cultivadas; Colesterol/análise; Colesterol/biossíntese; Colesterol 7-alfa-Hidroxilase/genética; Relação Dose-Resposta a Droga; Dislipidemias; Fator 4 Nuclear de Hepatócito/metabolismo; Humanos; Regiões Promotoras Genéticas/genética

Palavras-chave

cholesterol metabolism; cytochrome P450; nuclear receptors; retinoids/vitamin A; toxicology

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tretinoína / Colesterol 7-alfa-Hidroxilase / Fator de Transcrição AP-1 / Fator 4 Nuclear de Hepatócito Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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