MMP-13 Polymorphism as a Risk Factor in Implant Loss.

ABSTRACT

PURPOSE: To investigate whether MMP-13 g.-77 A > G (rs2252070) gene polymorphism is associated with early implants loss. MATERIALS AND METHODS: Two hundred nonsmoking volunteers in good oral health, > 18 years of age, and found to be periodontally healthy by clinical examination were matched by age, sex, and implant position and separated into two groups control group (100 patients with one or more healthy implants for a minimum of 1 year) and test group (100 patients who had suffered early implant loss, considered when implants presented mobility and/or pain before or during abutment connection, requiring their removal). Genomic DNA from saliva was genotyped by PCR-RFLP. Statistical analysis of the results was done using Mann-Whitney U and chi-square tests, with a significance level of 5%. RESULTS: A significant difference in the presence of the different alleles and genotype was found between groups for the MMP-13 g.-77 A > G (rs2252070) gene polymorphism (P = .0161, OR 95% = 0.57 [0.37 to 0.89]; P = .007, OR 95% = 0.44 [0.25 to 0.78]). The A allele increased susceptibility to early implant loss and appeared to be a genetic risk factor. CONCLUSION: The findings suggest that MMP-13 g.-77 A > G (rs2252070) polymorphism may contribute to early implants loss.