Your browser doesn't support javascript.
loading
CD4CD8 Double Positive T cell responses during Mycobacterium tuberculosis infection in cynomolgus macaques.
Diedrich, Collin Richard; Gideon, Hannah Priyadarshini; Rutledge, Tara; Baranowski, Tonilynn Marie; Maiello, Pauline; Myers, Amy J; Lin, Philana Ling.
Afiliação
  • Diedrich CR; Department of Pediatrics, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
  • Gideon HP; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
  • Rutledge T; Department of Pediatrics, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
  • Baranowski TM; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
  • Maiello P; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
  • Myers AJ; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
  • Lin PL; Department of Pediatrics, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
J Med Primatol ; 48(2): 82-89, 2019 04.
Article em En | MEDLINE | ID: mdl-30723927
ABSTRACT

BACKGROUND:

Tuberculosis (TB) kills millions of people every year. CD4 and CD8 T cells are critical in the immune response against TB. T cells expressing both CD4 and CD8 (CD4CD8 T cells) are functionally active and have not been examined in the context of TB.

METHODS:

We examine peripheral blood mononuclear cells (PBMC) and bronchoalveolar lavage cells (BAL) and lung granulomas from 28 cynomolgus macaques during Mycobacterium tuberculosis (Mtb) infection.

RESULTS:

CD4CD8 T cells increase in frequency during early Mtb infection in PBMC and BAL from pre-infection. Peripheral, airway, and lung granuloma CD4CD8 T cells have distinct patterns and greater cytokine production than CD4 or CD8 T cells.

CONCLUSION:

Our data suggest that CD4CD8 T cells transient the blood and airways early during infection to reach the granulomas where they are involved directly in the host response to Mtb.
Assuntos
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tuberculose / Linfócitos T CD4-Positivos / Linfócitos T CD8-Positivos / Macaca fascicularis Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tuberculose / Linfócitos T CD4-Positivos / Linfócitos T CD8-Positivos / Macaca fascicularis Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article