CD4CD8 Double Positive T cell responses during Mycobacterium tuberculosis infection in cynomolgus macaques.
J Med Primatol
; 48(2): 82-89, 2019 04.
Article
em En
| MEDLINE
| ID: mdl-30723927
ABSTRACT
BACKGROUND:
Tuberculosis (TB) kills millions of people every year. CD4 and CD8 T cells are critical in the immune response against TB. T cells expressing both CD4 and CD8 (CD4CD8 T cells) are functionally active and have not been examined in the context of TB.METHODS:
We examine peripheral blood mononuclear cells (PBMC) and bronchoalveolar lavage cells (BAL) and lung granulomas from 28 cynomolgus macaques during Mycobacterium tuberculosis (Mtb) infection.RESULTS:
CD4CD8 T cells increase in frequency during early Mtb infection in PBMC and BAL from pre-infection. Peripheral, airway, and lung granuloma CD4CD8 T cells have distinct patterns and greater cytokine production than CD4 or CD8 T cells.CONCLUSION:
Our data suggest that CD4CD8 T cells transient the blood and airways early during infection to reach the granulomas where they are involved directly in the host response to Mtb.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tuberculose
/
Linfócitos T CD4-Positivos
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Linfócitos T CD8-Positivos
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Macaca fascicularis
Limite:
Animals
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article