Genetic Risk Factors for Alzheimer Disease: Emerging Roles of Microglia in Disease Pathomechanisms.

Takatori, Sho; Wang, Wenbo; Iguchi, Akihiro; Tomita, Taisuke

Takatori, Sho; Wang, Wenbo; Iguchi, Akihiro; Tomita, Taisuke.

Afiliação

Takatori S; Laboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
Wang W; Laboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
Iguchi A; Laboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
Tomita T; Laboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan. taisuke@mol.f.u-tokyo.ac.jp.

Adv Exp Med Biol ; 1118: 83-116, 2019.

Article em En | MEDLINE | ID: mdl-30747419

Assuntos

Doença de Alzheimer/genética; Microglia/patologia; Doença de Alzheimer/patologia; Peptídeos beta-Amiloides/genética; Encéfalo/patologia; Humanos; Glicoproteínas de Membrana/genética; Receptores Imunológicos/genética; Fatores de Risco; Proteínas tau/genética

Palavras-chave

Alzheimer disease (AD); Amyloid hypothesis; Amyloid ß (Aß); Genetic risk factor; Genome-wide association study (GWAS); Microglia; Neurodegenerative disease; Neuroinflammation; Rare variant; Single nucleotide polymorphism (SNP); Sporadic AD; Tau; Triggering receptor expressed on myeloid cells 2 (TREM2)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Microglia / Doença de Alzheimer Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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