Left rostrolateral prefrontal cortex lesions reduce suicidal ideation in penetrating traumatic brain injury.
CNS Spectr
; 25(1): 24-31, 2020 02.
Article
em En
| MEDLINE
| ID: mdl-30968811
ABSTRACT
OBJECTIVES:
The objective of this study is to evaluate the relationship between suicidal ideation (SI), structural brain damage, and cognitive deficits in patients with penetrating traumatic brain injury (pTBI).METHODS:
Vietnam War veterans (n = 142) with pTBI to the prefrontal cortex (PFC) underwent combination of neuropsychological and psychiatric examinations and non-contrast CT brain scan. Patients were divided into SI positive (SI+) and SI negative (SI-) groups according to the SI item of the Beck Depression Inventory.RESULTS:
Lesions to the left rostrolateral PFC (rlPFC) were associated with a lower risk of SI independent of depression and global functioning. Left rlPFC lesion also reduced abstract reasoning skills, which mediated the lesion effects on suicide ideation.CONCLUSIONS:
The left rlPFC plays a crucial role in SI independently of depression and global functioning.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Córtex Pré-Frontal
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Traumatismos Cranianos Penetrantes
/
Ideação Suicida
/
Lesões Encefálicas Traumáticas
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
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Male
/
Middle aged
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article