Anacardic acid inhibits RANKL-induced osteoclastogenesis <i>in vitro</i> and prevents ovariectomy-induced bone loss <i>in vivo</i>.

Zhao, Kangxian; Jia, Yewei; Peng, Jiaxuan; Pang, Cong; Zhang, Tan; Han, Weiqi; Jiang, Jiawei; Lu, Xuanyuan; Zhu, Jiling; Qian, Yu

Anacardic acid inhibits RANKL-induced osteoclastogenesis in vitro and prevents ovariectomy-induced bone loss in vivo.

Zhao, Kangxian; Jia, Yewei; Peng, Jiaxuan; Pang, Cong; Zhang, Tan; Han, Weiqi; Jiang, Jiawei; Lu, Xuanyuan; Zhu, Jiling; Qian, Yu.

Afiliação

Zhao K; Department of Orthopedics, Shaoxing People's Hospital, Shaoxing Hospital, Zhejiang University School of Medicine, Shaoxing, China.
Jia Y; The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Peng J; Department of Orthopedics, Shaoxing Hospital, Zhejiang University School of Medicine, Shaoxing, China.
Pang C; Guangxi Key Laboratory of Regenerative Medicine, Guangxi Medical University, Nanning, China; and.
Zhang T; Guangxi Key Laboratory of Regenerative Medicine, Guangxi Medical University, Nanning, China; and.
Han W; Department of Orthopedics, Shaoxing People's Hospital, Shaoxing Hospital, Zhejiang University School of Medicine, Shaoxing, China.
Jiang J; Department of Orthopedics, Shaoxing People's Hospital, Shaoxing Hospital, Zhejiang University School of Medicine, Shaoxing, China.
Lu X; Department of Orthopedics, Shaoxing People's Hospital, Shaoxing Hospital, Zhejiang University School of Medicine, Shaoxing, China.
Zhu J; Department of Orthopedics, Shaoxing Hospital, Zhejiang University School of Medicine, Shaoxing, China.
Qian Y; Department of Orthopedics, Shaoxing People's Hospital, Shaoxing Hospital, Zhejiang University School of Medicine, Shaoxing, China.

FASEB J ; 33(8): 9100-9115, 2019 08.

Article em En | MEDLINE | ID: mdl-31050917

Assuntos

Ácidos Anacárdicos/farmacologia; Reabsorção Óssea/tratamento farmacológico; Osteoclastos/efeitos dos fármacos; Ligante RANK/metabolismo; Células 3T3; Transporte Ativo do Núcleo Celular; Animais; Reabsorção Óssea/etiologia; Reabsorção Óssea/metabolismo; Modelos Animais de Doenças; Feminino; Humanos; Técnicas In Vitro; Macrófagos/efeitos dos fármacos; Macrófagos/metabolismo; Macrófagos/patologia; Masculino; Camundongos; Camundongos Endogâmicos C57BL; NF-kappa B/metabolismo; Osteoclastos/metabolismo; Osteoclastos/patologia; Osteogênese/efeitos dos fármacos; Osteoporose Pós-Menopausa/tratamento farmacológico; Osteoporose Pós-Menopausa/metabolismo; Osteoporose Pós-Menopausa/patologia; Ovariectomia/efeitos adversos; Células RAW 264.7; Transdução de Sinais/efeitos dos fármacos; Fator de Transcrição RelA/metabolismo

Palavras-chave

AKT; MAPK; NF-κB; TAK1; osteoclast

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Osteoclastos / Reabsorção Óssea / Ácidos Anacárdicos / Ligante RANK Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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