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Biomimetic hydroxyapatite/poly xylitol sebacic adibate/vitamin K nanocomposite for enhancing bone regeneration.
Dai, Zhipeng; Dang, Minyan; Zhang, Wenzhi; Murugan, Sumathra; Teh, Seoh Wei; Pan, Haiyan.
Afiliação
  • Dai Z; a Department of Orthopedics , Henan Provincial People's Hospital , Zhengzhou City , Henan Province , China.
  • Dang M; b Innoscience Research SdnBhd , Subang Jaya , Selangor , Malaysia.
  • Zhang W; b Innoscience Research SdnBhd , Subang Jaya , Selangor , Malaysia.
  • Murugan S; c Biomaterials in Medicinal Chemistry Laboratory, Department of Natural Products Chemistry, School of Chemistry , Madurai Kamaraj University , Madurai , Tamil Nadu , India.
  • Teh SW; d Department of Biomedical Science , University Putra Malaysia (UPM) , Serdang , Malaysia.
  • Pan H; e Department of Orthopaedics , Ankang Hospital of Traditional Chinese Medicine , Ankang , Shaanxi Province , China.
Artif Cells Nanomed Biotechnol ; 47(1): 1898-1907, 2019 Dec.
Article em En | MEDLINE | ID: mdl-31066314
Hydroxyapatite (HAP) is a significant bone mineral that establishes bone strength. HAP composites in combination with biodegradable and bioactive polymer poly xylitol sebacic adipate (PXSA) would result in a constant release at target sites. Numerous studies have shown that vitamin K (VK) might possess a vital function in bone metabolism. The purpose of the present study was to inspect the synthesized composite HAP/PXSA/VK in developing polymeric biomaterials composite for the application of bone tissue regeneration. FTIR, X-ray diffraction, SEM and TEM techniques were applied to characterize the prepared composites. The release of VK from the HAP/PXSA/VK composite was evidenced through UV-Vis spectroscopy. In vitro studies proved that the HAP/PXSA/VK composite is appropriate for mesenchymal stem cell culture. Compared to pure HAP prepared following the same method, HAP/PXSA/VK composite provided favourable microstructures and good biodegradation distinctiveness for the application of tissue engineering, as well as tissue in-growth characteristics and improved scaffold cell penetration. This work reveals that the HAP/PXSA/VK composites have the potential for applications in bone tissue engineering.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vitamina K / Xilitol / Regeneração Óssea / Durapatita / Ácidos Decanoicos / Materiais Biomiméticos / Ácidos Dicarboxílicos / Nanocompostos Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vitamina K / Xilitol / Regeneração Óssea / Durapatita / Ácidos Decanoicos / Materiais Biomiméticos / Ácidos Dicarboxílicos / Nanocompostos Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article