A novel derivative of artemisinin inhibits cell proliferation and metastasis via down-regulation of cathepsin K in breast cancer.

Gu, Xiangyu; Peng, Yayuan; Zhao, Yuyu; Liang, Xin; Tang, Yun; Liu, Jianwen

Gu, Xiangyu; Peng, Yayuan; Zhao, Yuyu; Liang, Xin; Tang, Yun; Liu, Jianwen.

Afiliação

Gu X; State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
Peng Y; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
Zhao Y; State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
Liang X; State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China. Electronic address:
Tang Y; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China. Electronic address: ytang234@ecust.edu.cn.
Liu J; State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China. Electronic address:

Eur J Pharmacol ; 858: 172382, 2019 Sep 05.

Article em En | MEDLINE | ID: mdl-31112710

Assuntos

Artemisininas/farmacologia; Neoplasias da Mama/patologia; Catepsina K/genética; Regulação para Baixo/efeitos dos fármacos; Apoptose/efeitos dos fármacos; Linhagem Celular Tumoral; Movimento Celular/efeitos dos fármacos; Proliferação de Células/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Humanos; Metástase Neoplásica; Testosterona/farmacologia; Proteína bcl-X/metabolismo

Palavras-chave

Bcl-xL; Breast cancer; Cathepsin K; SM934; Testosterone

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Regulação para Baixo / Artemisininas / Catepsina K Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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