Prevalence of abnormal glucose homeostasis in Chinese patients with non-transfusion-dependent thalassemia.
Diabetes Metab Syndr Obes
; 12: 457-468, 2019.
Article
em En
| MEDLINE
| ID: mdl-31114275
ABSTRACT
Purpose:
To determine the prevalence and underlying pathology of abnormal glucose homeostasis in Chinese patients with non-transfusion-dependent thalassemia (NTDT). Patients andmethods:
In this study, we enrolled 211 patients aged 4-63 years with NTDT, including 79 ß thalassemia intermedia patients, 114 Hb H disease patients and 18 Hb E/ß thalassemia patients. All had oral glucose tolerance test, serum ferritin (SF), homeostasis model assessment (HOMA) and liver iron concentration (LIC) measurement. One hundred and twenty healthy age-matched controls were also used for the comparative purpose. Iron load was assessed by using SF and hepatic load by LIC using validated MRI techniques.Results:
The 211 patients were divided into three groups according to their fasting and 2 hrs postprandial blood glucose levels hypoglycemic, normal glucose tolerance (NGT) and hyperglycemic groups. In this study, 149 patients had NGT, 33 had hypoglycemia, 4 had diabetes and 25 had impaired glucose tolerance (IGT). None had impaired fasting glucose. There was a significant correlation between 2 hrs postprandial blood glucose levels and age, PINS120, HOMA-IR, alanine aminotransferase and LIC (P<0.05). Risk factors for IGT in NTDT patients were older age (≥24 years) and SF concentration of ≥2,500 ng/mL.Conclusion:
Age ≥24 years and SF ≥2,500 ng/mL of NTDT patients were at a greater risk for impaired glucose tolerance.
Texto completo:
1
Base de dados:
MEDLINE
Tipo de estudo:
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article