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Structural basis of resistance of mutant RET protein-tyrosine kinase to its inhibitors nintedanib and vandetanib.
Terzyan, Simon S; Shen, Tao; Liu, Xuan; Huang, Qingling; Teng, Peng; Zhou, Mi; Hilberg, Frank; Cai, Jianfeng; Mooers, Blaine H M; Wu, Jie.
Afiliação
  • Terzyan SS; From the Departments of Biochemistry and Molecular Biology and.
  • Shen T; the Laboratory of Biomolecular Structure and Function, and.
  • Liu X; Pathology.
  • Huang Q; the Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104.
  • Teng P; Pathology.
  • Zhou M; the Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104.
  • Hilberg F; the Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612.
  • Cai J; the Department of Chemistry, University of South Florida, Tampa, Florida 33620, and.
  • Mooers BHM; the Department of Chemistry, University of South Florida, Tampa, Florida 33620, and.
  • Wu J; the Department of Pharmacology, Boehringer Ingelheim, 1121 Vienna, Austria.
J Biol Chem ; 294(27): 10428-10437, 2019 07 05.
Article em En | MEDLINE | ID: mdl-31118272
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperidinas / Quinazolinas / Inibidores de Proteínas Quinases / Proteínas Proto-Oncogênicas c-ret / Indóis Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperidinas / Quinazolinas / Inibidores de Proteínas Quinases / Proteínas Proto-Oncogênicas c-ret / Indóis Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article