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Ibuprofen enhances synaptic function and neural progenitors proliferation markers and improves neuropathology and motor coordination in Machado-Joseph disease models.
Mendonça, Liliana S; Nóbrega, Clévio; Tavino, Silvia; Brinkhaus, Maximilian; Matos, Carlos; Tomé, Sandra; Moreira, Ricardo; Henriques, Daniel; Kaspar, Brian K; Pereira de Almeida, Luís.
Afiliação
  • Mendonça LS; Vectors and Gene Therapy Group, Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.
  • Nóbrega C; Vectors and Gene Therapy Group, Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.
  • Tavino S; Vectors and Gene Therapy Group, Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.
  • Brinkhaus M; Vectors and Gene Therapy Group, Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.
  • Matos C; Vectors and Gene Therapy Group, Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.
  • Tomé S; Vectors and Gene Therapy Group, Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.
  • Moreira R; Vectors and Gene Therapy Group, Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.
  • Henriques D; Vectors and Gene Therapy Group, Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.
  • Kaspar BK; The Research Institute at Nationwide Children's Hospital, Ohio State University School of Medicine, Columbus, Ohio 43205, USA.
  • Pereira de Almeida L; Vectors and Gene Therapy Group, Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.
Hum Mol Genet ; 28(22): 3691-3703, 2019 11 15.
Article em En | MEDLINE | ID: mdl-31127937
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sinapses / Ibuprofeno / Doença de Machado-Joseph Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sinapses / Ibuprofeno / Doença de Machado-Joseph Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article