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Optimization of an optrode microdevice for infrared neural stimulation.
Appl Opt ; 58(14): 3870-3876, 2019 May 10.
Article em En | MEDLINE | ID: mdl-31158202
Infrared light is a promising candidate for the treatment of neurodegenerative diseases. Optimizing the device parameters to achieve the best optical and mechanical performance is essential for reliable in vivo operation. In this work, mechanical strength simulations and coupled optical and thermal model were used to determine optimal design parameters for maximizing overall device efficiency. Our analysis reveals that minimizing the number of integrated optical elements and optimizing the optical path leads to a 33% relative in-coupling efficiency improvement at equal mechanical robustness. Using a symmetric optrode tip with an angle of 15°, the efficiency showed a further 17% relative improvement due to the enhancement of out-coupling at the tip. To investigate the temperature rise of the brain tissue during the infrared stimulation in the case of the optimized device, a thermal simulation with pulsed infrared excitation was developed. Our results show that the optimized device provides a temperature rise of 4.42°C as opposed to 3°C for the original setup.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Optogenética / Neurônios Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Optogenética / Neurônios Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article