How, When, and Where Do Human ß-Cells Regenerate?
Curr Diab Rep
; 19(8): 48, 2019 06 27.
Article
em En
| MEDLINE
| ID: mdl-31250214
ABSTRACT
PURPOSE OF REVIEW Pancreatic ß-cells play a critical role in whole-body glucose homeostasis by regulating the release of insulin in response to minute by minute alterations in metabolic demand. As such, ß-cells are staunchly resilient but there are circumstances where they can become functionally compromised or physically lost due to pathophysiological changes which culminate in overt hyperglycemia and diabetes. RECENT FINDINGS:
In humans, ß-cell mass appears to be largely defined in the postnatal period and this early replicative and generative phase is followed by a refractory state which persists throughout life. Despite this, efforts to identify physiological and pharmacological factors which might re-initiate ß-cell replication (or cause the replenishment of ß-cells by neogenesis or transdifferentiation) are beginning to bear fruit. Controlled manipulation of ß-cell mass in humans still represents a holy grail for therapeutic intervention in diabetes, but progress is being made which may lead to ultimate success.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Diabetes Mellitus
/
Células Secretoras de Insulina
/
Hiperglicemia
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article