The genetic evolution of metastatic uveal melanoma.
Nat Genet
; 51(7): 1123-1130, 2019 07.
Article
em En
| MEDLINE
| ID: mdl-31253977
ABSTRACT
Uveal melanoma is a clinically distinct and particularly lethal subtype of melanoma originating from melanocytes in the eye. Here, we performed multi-region DNA sequencing of primary uveal melanomas and their matched metastases from 35 patients. We observed previously unknown driver mutations and established the order in which these and known driver mutations undergo selection. Metastases had genomic alterations distinct from their primary tumors; metastatic dissemination sometimes occurred early during the development of the primary tumor. Our study offers new insights into the genetics and evolution of this melanoma subtype, providing potential biomarkers for progression and therapy.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Uveais
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Biomarcadores Tumorais
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Regulação Neoplásica da Expressão Gênica
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Evolução Molecular
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Genômica
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Neoplasias Hepáticas
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Melanoma
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Mutação
Tipo de estudo:
Observational_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article