Mannan-binding lectin promotes keratinocyte to produce CXCL1 and enhances neutrophil infiltration at the early stages of psoriasis.

Zeng, Jiaqi; Chen, Xi; Lei, Ke; Wang, Di; Lin, Lin; Wang, Yajie; Li, Yao; Liu, Yunzhi; Zhang, Liyun; Zuo, Daming; Sun, Ledong

Zeng, Jiaqi; Chen, Xi; Lei, Ke; Wang, Di; Lin, Lin; Wang, Yajie; Li, Yao; Liu, Yunzhi; Zhang, Liyun; Zuo, Daming; Sun, Ledong.

Afiliação

Zeng J; Department of Dermatology, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou, China.
Chen X; School of Laboratory Medicine and Biotechnology, Institute of Molecular Immunology, Southern Medical University, Guangzhou, China.
Lei K; School of Basic Medical Sciences, Department of Immunology, Southern Medical University, Guangzhou, China.
Wang D; Department of Dermatology, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou, China.
Lin L; School of Laboratory Medicine and Biotechnology, Institute of Molecular Immunology, Southern Medical University, Guangzhou, China.
Wang Y; Department of Dermatology, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou, China.
Li Y; School of Laboratory Medicine and Biotechnology, Institute of Molecular Immunology, Southern Medical University, Guangzhou, China.
Liu Y; Department of Dermatology, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou, China.
Zhang L; School of Basic Medical Sciences, Department of Immunology, Southern Medical University, Guangzhou, China.
Zuo D; Department of Dermatology, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou, China.
Sun L; Department of Dermatology, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou, China.

Exp Dermatol ; 28(9): 1017-1024, 2019 09.

Article em En | MEDLINE | ID: mdl-31260126

Assuntos

Quimiocina CXCL1/biossíntese; Quimiotaxia de Leucócito; Queratinócitos/metabolismo; Lectina de Ligação a Manose/fisiologia; Neutrófilos/fisiologia; Psoríase/imunologia; Animais; Linhagem Celular Transformada; Quimiocina CXCL1/genética; Derme/imunologia; Derme/patologia; Feminino; Humanos; Imiquimode/toxicidade; Inflamação; Queratinócitos/efeitos dos fármacos; Lectina de Ligação a Manose/deficiência; Lectina de Ligação a Manose/genética; Lectina de Ligação a Manose/imunologia; Lectina de Ligação a Manose/farmacologia; Erros Inatos do Metabolismo/complicações; Erros Inatos do Metabolismo/imunologia; Camundongos; Camundongos Knockout; Psoríase/induzido quimicamente; Psoríase/metabolismo; Organismos Livres de Patógenos Específicos; Regulação para Cima

Palavras-chave

imiquimod; keratinocyte; mannan-binding lectin; neutrophil; psoriasis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Psoríase / Queratinócitos / Quimiotaxia de Leucócito / Lectina de Ligação a Manose / Quimiocina CXCL1 / Neutrófilos Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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