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The prostate cancer risk variant rs55958994 regulates multiple gene expression through extreme long-range chromatin interaction to control tumor progression.
Qian, Yuyang; Zhang, Lei; Cai, Mingyang; Li, Hongxia; Xu, Heming; Yang, Hongzhen; Zhao, Zhongfang; Rhie, Suhn Kyong; Farnham, Peggy J; Shi, Jiandang; Lu, Wange.
Afiliação
  • Qian Y; State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, 94 Weijin Road, 300071 Tianjin, China.
  • Zhang L; State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, 94 Weijin Road, 300071 Tianjin, China.
  • Cai M; Department of Stem Cell Biology and Regenerative Medicine, Broad Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
  • Li H; State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, 94 Weijin Road, 300071 Tianjin, China.
  • Xu H; State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, 94 Weijin Road, 300071 Tianjin, China.
  • Yang H; State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, 94 Weijin Road, 300071 Tianjin, China.
  • Zhao Z; State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, 94 Weijin Road, 300071 Tianjin, China.
  • Rhie SK; Department of Biochemistry and Molecular Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
  • Farnham PJ; Department of Biochemistry and Molecular Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
  • Shi J; State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, 94 Weijin Road, 300071 Tianjin, China.
  • Lu W; Department of Stem Cell Biology and Regenerative Medicine, Broad Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Sci Adv ; 5(7): eaaw6710, 2019 07.
Article em En | MEDLINE | ID: mdl-31328168
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Cromatina / Regulação Neoplásica da Expressão Gênica / Progressão da Doença / Predisposição Genética para Doença / Polimorfismo de Nucleotídeo Único Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Cromatina / Regulação Neoplásica da Expressão Gênica / Progressão da Doença / Predisposição Genética para Doença / Polimorfismo de Nucleotídeo Único Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article