A highly diastereoselective [5+1] annulation to 2,2,3-trisubstituted tetrahydroquinoxalines via intramolecular Mannich-type trapping of ammonium ylides.
Chem Commun (Camb)
; 55(66): 9809-9812, 2019 Aug 13.
Article
em En
| MEDLINE
| ID: mdl-31360958
ABSTRACT
A novel tandem intermolecular ammonium ylide formation/intramolecular Mannich-type [5+1] cyclization reaction of aryl diazoacetates and ortho-aminophenyl imine derivatives was developed. The reaction provides an efficient methodology for direct synthesis of diverse trisubstituted tetrahydroquinoxalines bearing a quaternary stereogenic carbon center in moderate to good yields with excellent diastereoselectivity. This process features high efficiency, mild reaction conditions, and high stereoselectivity.
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MEDLINE
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En
Ano de publicação:
2019
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Article