Inhibition of the ULK1 protein complex suppresses <i>Staphylococcus</i>-induced autophagy and cell death.

Radhi, Ohood A; Davidson, Scott; Scott, Fiona; Zeng, Run X; Jones, D Heulyn; Tomkinson, Nicholas C O; Yu, Jun; Chan, Edmond Y W

Inhibition of the ULK1 protein complex suppresses Staphylococcus-induced autophagy and cell death.

Radhi, Ohood A; Davidson, Scott; Scott, Fiona; Zeng, Run X; Jones, D Heulyn; Tomkinson, Nicholas C O; Yu, Jun; Chan, Edmond Y W.

Afiliação

Radhi OA; Strathclyde Institute for Pharmacy and Biomedical Science, University of Strathclyde, Glasgow G4-0RE, Scotland, United Kingdom.
Davidson S; Strathclyde Institute for Pharmacy and Biomedical Science, University of Strathclyde, Glasgow G4-0RE, Scotland, United Kingdom.
Scott F; WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow G1-1XL, Scotland, United Kingdom.
Zeng RX; Department of Biomedical and Medical Sciences, Queen's University, Kingston, Ontario K7L 3N6, Canada.
Jones DH; WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow G1-1XL, Scotland, United Kingdom.
Tomkinson NCO; WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow G1-1XL, Scotland, United Kingdom.
Yu J; Strathclyde Institute for Pharmacy and Biomedical Science, University of Strathclyde, Glasgow G4-0RE, Scotland, United Kingdom.
Chan EYW; Strathclyde Institute for Pharmacy and Biomedical Science, University of Strathclyde, Glasgow G4-0RE, Scotland, United Kingdom eywc@queensu.ca.

J Biol Chem ; 294(39): 14289-14307, 2019 09 27.

Article em En | MEDLINE | ID: mdl-31387948

Assuntos

Proteína Homóloga à Proteína-1 Relacionada à Autofagia/metabolismo; Autofagia; Peptídeos e Proteínas de Sinalização Intracelular/metabolismo; Staphylococcus/patogenicidade; Autofagossomos; Proteína Homóloga à Proteína-1 Relacionada à Autofagia/antagonistas & inibidores; Proteínas Relacionadas à Autofagia/genética; Proteínas Relacionadas à Autofagia/metabolismo; Morte Celular/efeitos dos fármacos; Citoplasma/metabolismo; Citoplasma/microbiologia; Inibidores Enzimáticos/farmacologia; Células HEK293; Células HeLa; Humanos; Peptídeos e Proteínas de Sinalização Intracelular/antagonistas & inibidores; Lisossomos/metabolismo; Lisossomos/microbiologia; Salmonella/patogenicidade

Palavras-chave

Salmonella enterica; Staphylococcus aureus (S. aureus); Unc-51-like autophagy-activating kinase 1 (ULK1); autophagy; autophagy-related protein 13 (ATG13); bacterial pathogenesis; bacterial virulence; infection; intracellular pathogen; xenophagy

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autofagia / Staphylococcus / Peptídeos e Proteínas de Sinalização Intracelular / Proteína Homóloga à Proteína-1 Relacionada à Autofagia Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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