A novel hiPSC-derived system for hematoendothelial and myeloid blood toxicity screens identifies compounds promoting and inhibiting endothelial-to-hematopoietic transition.

Elcheva, Irina; Sneed, Mechelle; Frazee, Scott; Liu, Zhenqiu; Zhu, Junjia; Wood, Tyler; Hendrickson, Sara; Oehler, Chuck; Garcia, Brad; Spiegelman, Vladimir S

Elcheva, Irina; Sneed, Mechelle; Frazee, Scott; Liu, Zhenqiu; Zhu, Junjia; Wood, Tyler; Hendrickson, Sara; Oehler, Chuck; Garcia, Brad; Spiegelman, Vladimir S.

Afiliação

Elcheva I; Primorigen Biosciences Inc., Madison, WI 53719, USA; Division of Pediatric Hematology and Oncology, Department of Pediatrics, Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA. Electronic address: ielcheva@pennstatehealth.psu.edu.
Sneed M; Primorigen Biosciences Inc., Madison, WI 53719, USA.
Frazee S; Primorigen Biosciences Inc., Madison, WI 53719, USA.
Liu Z; Division of Pediatric Hematology and Oncology, Department of Pediatrics, Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA.
Zhu J; Division of Biostatistics and Bioinformatics, Department of Public Health Sciences, Pennsylvania State University, Cancer Institute, Hershey, PA 17033, USA.
Wood T; Division of Pediatric Hematology and Oncology, Department of Pediatrics, Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA.
Hendrickson S; Primorigen Biosciences Inc., Madison, WI 53719, USA.
Oehler C; Primorigen Biosciences Inc., Madison, WI 53719, USA.
Garcia B; Primorigen Biosciences Inc., Madison, WI 53719, USA.
Spiegelman VS; Division of Pediatric Hematology and Oncology, Department of Pediatrics, Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA.

Toxicol In Vitro ; 61: 104622, 2019 Dec.

Article em En | MEDLINE | ID: mdl-31404653

Assuntos

Avaliação Pré-Clínica de Medicamentos/métodos; Células Endoteliais/efeitos dos fármacos; Células-Tronco Hematopoéticas/efeitos dos fármacos; Diferenciação Celular/efeitos dos fármacos; Linhagem Celular; Sobrevivência Celular/efeitos dos fármacos; Células Endoteliais/metabolismo; Células-Tronco Hematopoéticas/metabolismo; Ensaios de Triagem em Larga Escala; Humanos; Células-Tronco Pluripotentes Induzidas/efeitos dos fármacos; Testes de Toxicidade/métodos; Transcriptoma/efeitos dos fármacos

Palavras-chave

Developmental toxicity; Endothelial-to-hematopoietic transition; Endothelial-to-mesenchymal transition; Hematopoiesis; Human induced pluripotent stem cells; Myeloid leukemia

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco Hematopoéticas / Células Endoteliais / Avaliação Pré-Clínica de Medicamentos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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