The synthesis of branched-chain fatty acids is limited by enzymatic decarboxylation of ethyl- and methylmalonyl-CoA.

Dewulf, Joseph P; Gerin, Isabelle; Rider, Mark H; Veiga-da-Cunha, Maria; Van Schaftingen, Emile; Bommer, Guido T

Dewulf, Joseph P; Gerin, Isabelle; Rider, Mark H; Veiga-da-Cunha, Maria; Van Schaftingen, Emile; Bommer, Guido T.

Afiliação

Dewulf JP; Laboratory of Physiological Chemistry, de Duve Institute, UCLouvain, Brussels B-1200, Belgium joseph.dewulf@uclouvain.be emile.vanschaftingen@uclouvain.be guido.bommer@uclouvain.be.
Gerin I; Walloon Excellence in Life Sciences and Biotechnology (WELBIO), UCLouvain, Brussels B-1200, Belgium.
Rider MH; Department of Laboratory Medicine, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels B-1200, Belgium.
Veiga-da-Cunha M; Laboratory of Physiological Chemistry, de Duve Institute, UCLouvain, Brussels B-1200, Belgium.
Van Schaftingen E; Walloon Excellence in Life Sciences and Biotechnology (WELBIO), UCLouvain, Brussels B-1200, Belgium.
Bommer GT; PHOS Laboratory, de Duve Institute, UCLouvain, Brussels B-1200, Belgium.

Biochem J ; 476(16): 2427-2447, 2019 08 30.

Article em En | MEDLINE | ID: mdl-31416829

Assuntos

Acil Coenzima A/metabolismo; Ácido Graxo Sintase Tipo I/metabolismo; Ácidos Graxos/biossíntese; Células 3T3-L1; Acil Coenzima A/genética; Animais; Descarboxilação; Ácido Graxo Sintase Tipo I/genética; Ácidos Graxos/genética; Camundongos

Palavras-chave

ECHDC1; branched-chain fatty acids; ethylmalonyl-CoA; fatty acid synthase; metabolite-repair; methylmalonyl-CoA

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Acil Coenzima A / Ácido Graxo Sintase Tipo I / Ácidos Graxos Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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