Dendrobium officinale polysaccharides alleviate colon tumorigenesis via restoring intestinal barrier function and enhancing anti-tumor immune response.

Liang, Jian; Li, Hailun; Chen, Jianqiang; He, Lian; Du, Xianhua; Zhou, Lian; Xiong, Qingping; Lai, Xiaoping; Yang, Yiqi; Huang, Song; Hou, Shaozhen

Liang, Jian; Li, Hailun; Chen, Jianqiang; He, Lian; Du, Xianhua; Zhou, Lian; Xiong, Qingping; Lai, Xiaoping; Yang, Yiqi; Huang, Song; Hou, Shaozhen.

Afiliação

Liang J; Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510006, Guangdong, PR China.
Li H; Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, 223002, Jiangsu, PR China.
Chen J; The First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, Guangdong, PR China.
He L; Guangdong Food and Drug Vocational College, Guangzhou, Guangdong, 510520, PR China.
Du X; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, Guangdong, PR China.
Zhou L; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, Guangdong, PR China.
Xiong Q; Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510006, Guangdong, PR China.
Lai X; Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510006, Guangdong, PR China.
Yang Y; Guangdong Metabolic Disease Research Center of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong, 510006, PR China. Electronic address: yangyiqi2011@163.com.
Huang S; Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510006, Guangdong, PR China. Electronic address: huangnn421@163.com.
Hou S; Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510006, Guangdong, PR China; School of Pharmaceutical Sciences, Guangzhou University of Chinese Med

Pharmacol Res ; 148: 104417, 2019 10.

Article em En | MEDLINE | ID: mdl-31473343

Assuntos

Antineoplásicos/farmacologia; Carcinogênese/efeitos dos fármacos; Colo/efeitos dos fármacos; Neoplasias Colorretais/tratamento farmacológico; Dendrobium/química; Mucosa Intestinal/efeitos dos fármacos; Polissacarídeos/farmacologia; Animais; Linfócitos T CD8-Positivos/efeitos dos fármacos; Linfócitos T CD8-Positivos/metabolismo; Colite/tratamento farmacológico; Colite/metabolismo; Colo/metabolismo; Neoplasias Colorretais/metabolismo; Inflamação/tratamento farmacológico; Inflamação/metabolismo; Mucosa Intestinal/metabolismo; Masculino; Mesalamina/farmacologia; Camundongos; Camundongos Endogâmicos BALB C; Ocludina/metabolismo; Transdução de Sinais/efeitos dos fármacos; Microambiente Tumoral/efeitos dos fármacos; Proteína da Zônula de Oclusão-1/metabolismo

Palavras-chave

Colorectal cancer; Dendrobium officinale; Intestinal barrier function; Tight junctions; Tumor-infiltrating T cells

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polissacarídeos / Neoplasias Colorretais / Colo / Dendrobium / Carcinogênese / Mucosa Intestinal / Antineoplásicos Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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