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Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials.
Bachert, Claus; Han, Joseph K; Desrosiers, Martin; Hellings, Peter W; Amin, Nikhil; Lee, Stella E; Mullol, Joaquim; Greos, Leon S; Bosso, John V; Laidlaw, Tanya M; Cervin, Anders U; Maspero, Jorge F; Hopkins, Claire; Olze, Heidi; Canonica, G Walter; Paggiaro, Pierluigi; Cho, Seong H; Fokkens, Wytske J; Fujieda, Shigeharu; Zhang, Mei; Lu, Xin; Fan, Chunpeng; Draikiwicz, Steven; Kamat, Siddhesh A; Khan, Asif; Pirozzi, Gianluca; Patel, Naimish; Graham, Neil M H; Ruddy, Marcella; Staudinger, Heribert; Weinreich, David; Stahl, Neil; Yancopoulos, George D; Mannent, Leda P.
Afiliação
  • Bachert C; Faculty of Medicine, Upper Airways Research Laboratory, Ghent University, Ghent, Belgium; CLINTEC, Karolinska Institutet, Stockholm, Sweden. Electronic address: claus.bachert@ugent.be.
  • Han JK; Division of Allergy, Eastern Virginia Medical School, Norfolk, VA, USA.
  • Desrosiers M; Centre de recherche du Centre hospitalier de l'Université de Montréal, Montreal, QC, Canada.
  • Hellings PW; Laboratory of Experimental Immunology, Department of Otorhinolaryngology-Head and Neck Surgery, University Hospitals Leuven, Leuven, Belgium.
  • Amin N; Regeneron Pharmaceuticals, Tarrytown, NY, USA.
  • Lee SE; Department of Otolaryngology-Head and Neck Surgery, Division of Sinonasal Disorders and Allergy, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
  • Mullol J; Hospital Clínic, IDIBAPS, Universitat de Barcelona, CIBERES, Barcelona, Spain.
  • Greos LS; Colorado Allergy and Asthma Centers, Centennial, CO, USA.
  • Bosso JV; Department of Otorhinolaryngology-Head and Neck Surgery, Division of Rhinology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.
  • Laidlaw TM; Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, USA.
  • Cervin AU; Faculty of Medicine, University of Queensland and Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia.
  • Maspero JF; Allergy and Respiratory Research Unit, Fundación CIDEA, Buenos Aires, Argentina.
  • Hopkins C; Department of Ear, Nose, and Throat, Guy's and St Thomas' Hospitals, London, UK.
  • Olze H; Department of Otorhinolaryngology, Head and Neck Surgery, Charité-Universitätsmedizin Berlin, Berlin, Germany.
  • Canonica GW; Personalized Medicine Asthma & Allergy, Humanitas University, Clinical and Research Center, IRCCS, Milan, Italy.
  • Paggiaro P; Department of Surgery, Medicine, Molecular Biology and Critical Care, University of Pisa, Pisa, Italy.
  • Cho SH; Division of Allergy-Immunology, University of South Florida, Tampa, FL, USA.
  • Fokkens WJ; Academic Medical Center, Amsterdam, Netherlands.
  • Fujieda S; Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
  • Zhang M; Sanofi, Bridgewater, NJ, USA.
  • Lu X; Sanofi, Bridgewater, NJ, USA.
  • Fan C; Sanofi, Bridgewater, NJ, USA.
  • Draikiwicz S; Sanofi, Bridgewater, NJ, USA.
  • Kamat SA; Regeneron Pharmaceuticals, Tarrytown, NY, USA.
  • Khan A; Sanofi, Chilly-Mazarin, France.
  • Pirozzi G; Sanofi, Bridgewater, NJ, USA.
  • Patel N; Sanofi, Cambridge, MA, USA.
  • Graham NMH; Regeneron Pharmaceuticals, Tarrytown, NY, USA.
  • Ruddy M; Regeneron Pharmaceuticals, Tarrytown, NY, USA.
  • Staudinger H; Sanofi, Bridgewater, NJ, USA.
  • Weinreich D; Regeneron Pharmaceuticals, Tarrytown, NY, USA.
  • Stahl N; Regeneron Pharmaceuticals, Tarrytown, NY, USA.
  • Yancopoulos GD; Regeneron Pharmaceuticals, Tarrytown, NY, USA.
  • Mannent LP; Sanofi, Chilly-Mazarin, France.
Lancet ; 394(10209): 1638-1650, 2019 11 02.
Article em En | MEDLINE | ID: mdl-31543428
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sinusite / Pólipos Nasais / Anticorpos Monoclonais Humanizados Tipo de estudo: Clinical_trials Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sinusite / Pólipos Nasais / Anticorpos Monoclonais Humanizados Tipo de estudo: Clinical_trials Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article