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Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells.
Chen, Pei-Hsuan; Cai, Ling; Huffman, Kenneth; Yang, Chendong; Kim, Jiyeon; Faubert, Brandon; Boroughs, Lindsey; Ko, Bookyung; Sudderth, Jessica; McMillan, Elizabeth A; Girard, Luc; Chen, Dong; Peyton, Michael; Shields, Misty D; Yao, Bo; Shames, David S; Kim, Hyun Seok; Timmons, Brenda; Sekine, Ikuo; Britt, Rebecca; Weber, Stephanie; Byers, Lauren A; Heymach, John V; Chen, Jing; White, Michael A; Minna, John D; Xiao, Guanghua; DeBerardinis, Ralph J.
Afiliação
  • Chen PH; Children's Medical Center Research Institute at UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA.
  • Cai L; Children's Medical Center Research Institute at UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA; Quantitative Biomedical Research Center, Department of Population and Data Sciences at UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA.
  • Huffman K; Hamon Center for Therapeutic Oncology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA.
  • Yang C; Children's Medical Center Research Institute at UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA.
  • Kim J; Children's Medical Center Research Institute at UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA.
  • Faubert B; Children's Medical Center Research Institute at UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA.
  • Boroughs L; Children's Medical Center Research Institute at UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA.
  • Ko B; Children's Medical Center Research Institute at UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA.
  • Sudderth J; Children's Medical Center Research Institute at UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA.
  • McMillan EA; Department of Cell Biology, UTSW Medical Center, Dallas, TX 75390, USA.
  • Girard L; Hamon Center for Therapeutic Oncology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA; Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390 USA.
  • Chen D; Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA.
  • Peyton M; Hamon Center for Therapeutic Oncology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA.
  • Shields MD; Hamon Center for Therapeutic Oncology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA.
  • Yao B; Quantitative Biomedical Research Center, Department of Population and Data Sciences at UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA.
  • Shames DS; Department of Oncology Biomarker Development, Genentech Inc., South San Francisco, CA 94080, USA.
  • Kim HS; Department of Cell Biology, UTSW Medical Center, Dallas, TX 75390, USA.
  • Timmons B; Hamon Center for Therapeutic Oncology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA.
  • Sekine I; Hamon Center for Therapeutic Oncology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA.
  • Britt R; Hamon Center for Therapeutic Oncology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA.
  • Weber S; Hamon Center for Therapeutic Oncology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA.
  • Byers LA; Department of Thoracic/Head and Neck Medical Oncology, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Heymach JV; Department of Thoracic/Head and Neck Medical Oncology, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Chen J; Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA.
  • White MA; Department of Cell Biology, UTSW Medical Center, Dallas, TX 75390, USA.
  • Minna JD; Hamon Center for Therapeutic Oncology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA; Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390 USA; Department of Internal Medicine, Universit
  • Xiao G; Quantitative Biomedical Research Center, Department of Population and Data Sciences at UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA.
  • DeBerardinis RJ; Children's Medical Center Research Institute at UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA. Electronic address: ralph.deberardinis@utsou
Mol Cell ; 76(5): 838-851.e5, 2019 12 05.
Article em En | MEDLINE | ID: mdl-31564558
Intermediary metabolism in cancer cells is regulated by diverse cell-autonomous processes, including signal transduction and gene expression patterns, arising from specific oncogenotypes and cell lineages. Although it is well established that metabolic reprogramming is a hallmark of cancer, we lack a full view of the diversity of metabolic programs in cancer cells and an unbiased assessment of the associations between metabolic pathway preferences and other cell-autonomous processes. Here, we quantified metabolic features, mostly from the 13C enrichment of molecules from central carbon metabolism, in over 80 non-small cell lung cancer (NSCLC) cell lines cultured under identical conditions. Because these cell lines were extensively annotated for oncogenotype, gene expression, protein expression, and therapeutic sensitivity, the resulting database enables the user to uncover new relationships between metabolism and these orthogonal processes.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Linhagem Celular Tumoral / Metaboloma Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Linhagem Celular Tumoral / Metaboloma Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article