Full-Length P2X<sub>7</sub> Structures Reveal How Palmitoylation Prevents Channel Desensitization.

McCarthy, Alanna E; Yoshioka, Craig; Mansoor, Steven E

Full-Length P2X₇ Structures Reveal How Palmitoylation Prevents Channel Desensitization.

McCarthy, Alanna E; Yoshioka, Craig; Mansoor, Steven E.

Afiliação

McCarthy AE; Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA; Knight Cardiovascular Institute, Oregon Health and Science University, Portland, OR 97239, USA.
Yoshioka C; Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97201, USA.
Mansoor SE; Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA; Knight Cardiovascular Institute, Oregon Health and Science University, Portland, OR 97239, USA. Electronic address: mansoors@ohsu.edu.

Cell ; 179(3): 659-670.e13, 2019 10 17.

Article em En | MEDLINE | ID: mdl-31587896

Assuntos

Lipoilação; Receptores Purinérgicos P2X7/química; Trifosfato de Adenosina/metabolismo; Animais; Sítios de Ligação; Microscopia Crioeletrônica; Guanosina/metabolismo; Células HEK293; Humanos; Simulação de Acoplamento Molecular; Simulação de Dinâmica Molecular; Ligação Proteica; Receptores Purinérgicos P2X7/metabolismo; Células Sf9; Spodoptera; Xenopus; Zinco/metabolismo

Palavras-chave

Apoptosis; Cryoelectron microscopy; Cytoplasmic domain; Desensitization; Guanosine nucleotides; Ligand gated ion channels; Palmitoylation; Purinergic (P2X) receptors; Structural biology; Zinc ion complex

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Lipoilação / Receptores Purinérgicos P2X7 Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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