Your browser doesn't support javascript.
loading
Clinical Variables and Genetic Risk Factors Associated with the Acute Outcome of Ischemic Stroke: A Systematic Review.
Torres-Aguila, Nuria P; Carrera, Caty; Muiño, Elena; Cullell, Natalia; Cárcel-Márquez, Jara; Gallego-Fabrega, Cristina; González-Sánchez, Jonathan; Bustamante, Alejandro; Delgado, Pilar; Ibañez, Laura; Heitsch, Laura; Krupinski, Jerzy; Montaner, Joan; Martí-Fàbregas, Joan; Cruchaga, Carlos; Lee, Jin-Moo; Fernandez-Cadenas, Israel.
Afiliação
  • Torres-Aguila NP; Stroke Pharmacogenomics and Genetics Laboratory, Sant Pau Research Institute, Barcelona, Spain.
  • Carrera C; Neurovascular Research Laboratory, Vall d'Hebron Research Institute (VHIR), Autonomous University of Barcelona, Barcelona, Spain.
  • Muiño E; Stroke Pharmacogenomics and Genetics Laboratory, Sant Pau Research Institute, Barcelona, Spain.
  • Cullell N; Neurovascular Research Laboratory, Vall d'Hebron Research Institute (VHIR), Autonomous University of Barcelona, Barcelona, Spain.
  • Cárcel-Márquez J; Stroke Pharmacogenomics and Genetics Laboratory, Sant Pau Research Institute, Barcelona, Spain.
  • Gallego-Fabrega C; Stroke Pharmacogenomics and Genetics Laboratory, Mutua Terrasa Foundation of Teaching and Research, Mutua Terrassa Hospital, Terrassa, Spain.
  • González-Sánchez J; Stroke Pharmacogenomics and Genetics Laboratory, Sant Pau Research Institute, Barcelona, Spain.
  • Bustamante A; Stroke Pharmacogenomics and Genetics Laboratory, Sant Pau Research Institute, Barcelona, Spain.
  • Delgado P; Stroke Pharmacogenomics and Genetics Laboratory, Mutua Terrasa Foundation of Teaching and Research, Mutua Terrassa Hospital, Terrassa, Spain.
  • Ibañez L; Stroke Pharmacogenomics and Genetics Laboratory, Sant Pau Research Institute, Barcelona, Spain.
  • Heitsch L; Stroke Pharmacogenomics and Genetics Laboratory, Mutua Terrasa Foundation of Teaching and Research, Mutua Terrassa Hospital, Terrassa, Spain.
  • Krupinski J; Health Care Science Department, The Manchester Metropolitan University of All Saints, Manchester, UK.
  • Montaner J; Neurovascular Research Laboratory, Vall d'Hebron Research Institute (VHIR), Autonomous University of Barcelona, Barcelona, Spain.
  • Martí-Fàbregas J; Neurovascular Research Laboratory, Vall d'Hebron Research Institute (VHIR), Autonomous University of Barcelona, Barcelona, Spain.
  • Cruchaga C; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
  • Lee JM; Division of Emergency Medicine, Washington University School of Medicine, St. Louis, MO, USA.
  • Fernandez-Cadenas I; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
J Stroke ; 21(3): 276-289, 2019 Sep.
Article em En | MEDLINE | ID: mdl-31590472
ABSTRACT
Stroke is a complex disease and one of the main causes of morbidity and mortality among the adult population. A huge variety of factors is known to influence patient outcome, including demographic variables, comorbidities or genetics. In this review, we expound what is known about the influence of clinical variables and related genetic risk factors on ischemic stroke outcome, focusing on acute and subacute outcome (within 24 to 48 hours after stroke and until day 10, respectively), as they are the first indicators of stroke damage. We searched the PubMed data base for articles that investigated the interaction between clinical variables or genetic factors and acute or subacute stroke outcome. A total of 61 studies were finally included in this review. Regarding the data collected, the variables consistently associated with acute stroke outcome are glucose levels, blood pressure, presence of atrial fibrillation, prior statin treatment, stroke severity, type of acute treatment performed, severe neurological complications, leukocyte levels, and genetic risk factors. Further research and international efforts are required in this field, which should include genome-wide association studies.
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Etiology_studies / Risk_factors_studies / Systematic_reviews Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Etiology_studies / Risk_factors_studies / Systematic_reviews Idioma: En Ano de publicação: 2019 Tipo de documento: Article