Visible-Light-Driven N-Heterocyclic Carbene Catalyzed γ- and ϵ-Alkylation with Alkyl Radicals.
Angew Chem Int Ed Engl
; 58(50): 18124-18130, 2019 Dec 09.
Article
em En
| MEDLINE
| ID: mdl-31595644
ABSTRACT
The merging of photoredox catalysis and N-heterocyclic carbene (NHC) catalysis for γ- and ϵ-alkylation of enals with alkyl radicals was developed. The alkylation reaction of γ-oxidized enals with alkyl halides worked well for the synthesis γ-multisubstituted-α,ß-unsaturated esters, including those with challenging vicinal all-carbon quaternary centers. The synthesis of ϵ-multisubstituted-α,ß-γ,δ-diunsaturated esters by an unprecedented NHC-catalyzed ϵ-functionalization was also established.
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MEDLINE
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En
Ano de publicação:
2019
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Article