Therapeutic inhibition of mTORC2 rescues the behavioral and neurophysiological abnormalities associated with Pten-deficiency.

Chen, Chien-Ju; Sgritta, Martina; Mays, Jacqunae; Zhou, Hongyi; Lucero, Rocco; Park, Jin; Wang, I-Ching; Park, Jun Hyoung; Kaipparettu, Benny Abraham; Stoica, Loredana; Jafar-Nejad, Paymaan; Rigo, Frank; Chin, Jeannie; Noebels, Jeffrey L; Costa-Mattioli, Mauro

Chen, Chien-Ju; Sgritta, Martina; Mays, Jacqunae; Zhou, Hongyi; Lucero, Rocco; Park, Jin; Wang, I-Ching; Park, Jun Hyoung; Kaipparettu, Benny Abraham; Stoica, Loredana; Jafar-Nejad, Paymaan; Rigo, Frank; Chin, Jeannie; Noebels, Jeffrey L; Costa-Mattioli, Mauro.

Afiliação

Chen CJ; Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA.
Sgritta M; Memory and Brain Research Center, Baylor College of Medicine, Houston, TX, USA.
Mays J; Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA.
Zhou H; Memory and Brain Research Center, Baylor College of Medicine, Houston, TX, USA.
Lucero R; Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA.
Park J; Memory and Brain Research Center, Baylor College of Medicine, Houston, TX, USA.
Wang IC; Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA.
Park JH; Memory and Brain Research Center, Baylor College of Medicine, Houston, TX, USA.
Kaipparettu BA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Stoica L; Department of Neurology, Baylor College of Medicine, Houston, TX, USA.
Jafar-Nejad P; Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA.
Rigo F; Memory and Brain Research Center, Baylor College of Medicine, Houston, TX, USA.
Chin J; Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA.
Noebels JL; Memory and Brain Research Center, Baylor College of Medicine, Houston, TX, USA.
Costa-Mattioli M; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.

Nat Med ; 25(11): 1684-1690, 2019 11.

Article em En | MEDLINE | ID: mdl-31636454

Assuntos

Alvo Mecanístico do Complexo 2 de Rapamicina/genética; Doenças do Sistema Nervoso/genética; PTEN Fosfo-Hidrolase/genética; Serina-Treonina Quinases TOR/genética; Animais; Encéfalo/metabolismo; Encéfalo/patologia; Modelos Animais de Doenças; Humanos; Mutação com Perda de Função/genética; Alvo Mecanístico do Complexo 1 de Rapamicina/genética; Camundongos; Camundongos Knockout; Doenças do Sistema Nervoso/metabolismo; Doenças do Sistema Nervoso/patologia; Oligonucleotídeos Antissenso/genética; Oligonucleotídeos Antissenso/farmacologia; PTEN Fosfo-Hidrolase/deficiência; Proteína Companheira de mTOR Insensível à Rapamicina/antagonistas & inibidores; Proteína Companheira de mTOR Insensível à Rapamicina/genética; Proteína 1 do Complexo Esclerose Tuberosa/genética

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: PTEN Fosfo-Hidrolase / Serina-Treonina Quinases TOR / Alvo Mecanístico do Complexo 2 de Rapamicina / Doenças do Sistema Nervoso Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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