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Adult sox10+ Cardiomyocytes Contribute to Myocardial Regeneration in the Zebrafish.
Sande-Melón, Marcos; Marques, Inês J; Galardi-Castilla, María; Langa, Xavier; Pérez-López, María; Botos, Marius-Alexandru; Sánchez-Iranzo, Héctor; Guzmán-Martínez, Gabriela; Ferreira Francisco, David Miguel; Pavlinic, Dinko; Benes, Vladimir; Bruggmann, Rémy; Mercader, Nadia.
Afiliação
  • Sande-Melón M; Spanish National Centre for Cardiovascular Research Carlos III (CNIC-ISCIII), 28029 Madrid, Spain; Institute of Anatomy, University of Bern, 3012 Bern, Switzerland.
  • Marques IJ; Institute of Anatomy, University of Bern, 3012 Bern, Switzerland.
  • Galardi-Castilla M; Spanish National Centre for Cardiovascular Research Carlos III (CNIC-ISCIII), 28029 Madrid, Spain.
  • Langa X; Institute of Anatomy, University of Bern, 3012 Bern, Switzerland.
  • Pérez-López M; Spanish National Centre for Cardiovascular Research Carlos III (CNIC-ISCIII), 28029 Madrid, Spain.
  • Botos MA; Institute of Anatomy, University of Bern, 3012 Bern, Switzerland.
  • Sánchez-Iranzo H; Spanish National Centre for Cardiovascular Research Carlos III (CNIC-ISCIII), 28029 Madrid, Spain.
  • Guzmán-Martínez G; Spanish National Centre for Cardiovascular Research Carlos III (CNIC-ISCIII), 28029 Madrid, Spain; Departamento de Cardiología, Hospital Universitario La Paz. IdiPaz, 28046 Madrid, Spain.
  • Ferreira Francisco DM; Interfaculty Bioinformatics Unit and Swiss Institute of Bioinformatics, University of Bern, 3012 Bern, Switzerland.
  • Pavlinic D; Genomics Core Facility, European Molecular Biology Laboratory (EMBL) Heidelberg, 69117 Heidelberg, Germany.
  • Benes V; Genomics Core Facility, European Molecular Biology Laboratory (EMBL) Heidelberg, 69117 Heidelberg, Germany.
  • Bruggmann R; Interfaculty Bioinformatics Unit and Swiss Institute of Bioinformatics, University of Bern, 3012 Bern, Switzerland.
  • Mercader N; Spanish National Centre for Cardiovascular Research Carlos III (CNIC-ISCIII), 28029 Madrid, Spain; Institute of Anatomy, University of Bern, 3012 Bern, Switzerland. Electronic address: nadia.mercader@ana.unibe.ch.
Cell Rep ; 29(4): 1041-1054.e5, 2019 10 22.
Article em En | MEDLINE | ID: mdl-31644901
ABSTRACT
During heart regeneration in the zebrafish, fibrotic tissue is replaced by newly formed cardiomyocytes derived from preexisting ones. It is unclear whether the heart is composed of several cardiomyocyte populations bearing different capacity to replace lost myocardium. Here, using sox10 genetic fate mapping, we identify a subset of preexistent cardiomyocytes in the adult zebrafish heart with a distinct gene expression profile that expanded after cryoinjury. Genetic ablation of sox10+ cardiomyocytes impairs cardiac regeneration, revealing that these cells play a role in heart regeneration.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regeneração / Proteínas de Peixe-Zebra / Miócitos Cardíacos / Fatores de Transcrição SOXE Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regeneração / Proteínas de Peixe-Zebra / Miócitos Cardíacos / Fatores de Transcrição SOXE Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article