Synthesis, Pharmacological Characterization, and Structure-Activity Relationships of Noncanonical Selective Agonists for &#945;7 nAChRs.

Camacho-Hernandez, Gisela Andrea; Stokes, Clare; Duggan, Brendan M; Kaczanowska, Katarzyna; Brandao-Araiza, Stefania; Doan, Lisa; Papke, Roger L; Taylor, Palmer

Synthesis, Pharmacological Characterization, and Structure-Activity Relationships of Noncanonical Selective Agonists for α7 nAChRs.

Camacho-Hernandez, Gisela Andrea; Stokes, Clare; Duggan, Brendan M; Kaczanowska, Katarzyna; Brandao-Araiza, Stefania; Doan, Lisa; Papke, Roger L; Taylor, Palmer.

Afiliação

Camacho-Hernandez GA; Department of Pharmacology, Skaggs School of Pharmacy & Pharmaceutical Sciences , University of California-San Diego , La Jolla , California 92093-0751 , United States.
Stokes C; Department of Pharmacology & Therapeutics , University of Florida , P.O. Box 100267, Gainesville , Florida 32610-0267 , United States.
Duggan BM; Department of Pharmacology, Skaggs School of Pharmacy & Pharmaceutical Sciences , University of California-San Diego , La Jolla , California 92093-0751 , United States.
Kaczanowska K; Department of Pharmacology, Skaggs School of Pharmacy & Pharmaceutical Sciences , University of California-San Diego , La Jolla , California 92093-0751 , United States.
Brandao-Araiza S; Department of Pharmacology, Skaggs School of Pharmacy & Pharmaceutical Sciences , University of California-San Diego , La Jolla , California 92093-0751 , United States.
Doan L; Department of Pharmacology, Skaggs School of Pharmacy & Pharmaceutical Sciences , University of California-San Diego , La Jolla , California 92093-0751 , United States.
Papke RL; Department of Pharmacology & Therapeutics , University of Florida , P.O. Box 100267, Gainesville , Florida 32610-0267 , United States.
Taylor P; Department of Pharmacology & Therapeutics , University of Florida , P.O. Box 100267, Gainesville , Florida 32610-0267 , United States.

J Med Chem ; 62(22): 10376-10390, 2019 11 27.

Article em En | MEDLINE | ID: mdl-31675224

Assuntos

Agonistas Nicotínicos/química; Agonistas Nicotínicos/farmacologia; Receptor Nicotínico de Acetilcolina alfa7/agonistas; Animais; Sítios de Ligação; Simulação por Computador; Avaliação Pré-Clínica de Medicamentos/métodos; Feminino; Humanos; Isoxazóis/farmacologia; Espectroscopia de Ressonância Magnética; Neurotransmissores/metabolismo; Agonistas Nicotínicos/síntese química; Oócitos/efeitos dos fármacos; Oócitos/metabolismo; Técnicas de Patch-Clamp; Compostos de Fenilureia/farmacologia; Relação Estrutura-Atividade; Xenopus laevis; Receptor Nicotínico de Acetilcolina alfa7/genética; Receptor Nicotínico de Acetilcolina alfa7/metabolismo

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Agonistas Nicotínicos / Receptor Nicotínico de Acetilcolina alfa7 Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google