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Sequential Palladium-Catalyzed Allylic Alkylation/retro-Dieckmann Fragmentation Strategy for the Synthesis of α-Substituted Acrylonitriles.
Katsina, Tania; Sharma, Sachi Prem; Buccafusca, Roberto; Quinn, Derek J; Moody, Thomas S; Arseniyadis, Stellios.
Afiliação
  • Katsina T; Queen Mary University of London , School of Biological and Chemical Sciences , Mile End Road , London E1 4NS , U.K.
  • Sharma SP; Queen Mary University of London , School of Biological and Chemical Sciences , Mile End Road , London E1 4NS , U.K.
  • Buccafusca R; Queen Mary University of London , School of Biological and Chemical Sciences , Mile End Road , London E1 4NS , U.K.
  • Quinn DJ; Almac Sciences , Department of Biocatalysis and Isotope Chemistry , Almac House, 20 Seagoe Industrial Estate , Craigavon BT63 5QD , Northern Ireland , U.K.
  • Moody TS; Almac Sciences , Department of Biocatalysis and Isotope Chemistry , Almac House, 20 Seagoe Industrial Estate , Craigavon BT63 5QD , Northern Ireland , U.K.
  • Arseniyadis S; Arran Chemical Company Limited , Unit 1 Monksland Industrial Estate , Athlone , Co. Roscommon , Ireland.
Org Lett ; 21(23): 9348-9352, 2019 12 06.
Article em En | MEDLINE | ID: mdl-31710491
A straightforward synthesis of α-substituted acrylonitriles is described using 4-cyano-3-oxotetrahydro-thiophene (c-THT) as an acrylonitrile surrogate. This unprecedented two-step sequence featuring a palladium-catalyzed allylic alkylation (Pd-AA) and a retro-Dieckmann fragmentation provides a general entry into diversely substituted 1,4-dienes.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2019 Tipo de documento: Article