Your browser doesn't support javascript.
loading
Cocaine Use and Pulmonary Hypertension.
Alzghoul, Bashar N; Abualsuod, Amjad; Alqam, Bilal; Innabi, Ayoub; Palagiri, Deepak R; Gheith, Zaid; Amer, Farah N; Meena, Nikhil K; Kenchaiah, Satish.
Afiliação
  • Alzghoul BN; Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas; Division of Pulmonary, Critical Care and Sleep Medicine, University of Florida, Gainesville, Florida; Department of Medicine, University of Florida, Gainesville, Florida.
  • Abualsuod A; Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas; Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
  • Alqam B; Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
  • Innabi A; Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas; Division of Pulmonary, Critical Care and Sleep Medicine, University of Florida, Gainesville, Florida; Department of Medicine, University of Florida, Gainesville, Florida.
  • Palagiri DR; Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
  • Gheith Z; Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
  • Amer FN; Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas; Department of Medicine, University of Florida, Gainesville, Florida.
  • Meena NK; Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas; Division of Pulmonary and Critical Care Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
  • Kenchaiah S; Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas; Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas; Cardiovascular Institute, Mount Sinai Hospital, New York, New York; Advanced Cardiovascular Im
Am J Cardiol ; 125(2): 282-288, 2020 01 15.
Article em En | MEDLINE | ID: mdl-31757354
ABSTRACT
Evidence linking cocaine to the risk of pulmonary hypertension (PH) is limited and inconsistent. We examined whether cocaine use, in the absence of other known causes of PH, was associated with elevated systolic pulmonary artery pressure (sPAP) and increased probability of PH. We compared patients with documented cocaine use to a randomly selected age, sex, and race-matched control group without history of cocaine use. All participants had no known causes of PH and underwent echocardiography for noninvasive estimation of sPAP. We used routinely reported echocardiographic parameters and contemporary guidelines to grade the probability of PH. In 88 patients with documented cocaine use (mean age ± standard deviation 51.7 ± 9.5 years), 33% were women and 89% were of Black race. The commonest route of cocaine use was smoking (74%). Cocaine users compared with the control group had significantly higher sPAP (mean ± standard deviation, 30.1 ± 13.1 vs 22.0 ± 9.8 mm Hg, p <0.001) and greater likelihood of PH (25% vs 10%, p = 0.012). In multivariable analyses adjusted for potential confounders including left ventricular diastolic dysfunction, cocaine use conferred a fivefold greater odds of echocardiographic PH (p = 0.006). Additionally, a stepwise increase in the likelihood of PH was noted across cocaine users with negative or no drug screen on the day of echocardiography to cocaine users with a positive drug screen (multivariable p for trend = 0.008). In conclusion, cocaine use was associated with a higher sPAP and an increased likelihood of echocardiographic PH with a probable acute-on-chronic effect.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Artéria Pulmonar / Ecocardiografia Doppler / Pressão Propulsora Pulmonar / Cocaína / Transtornos Relacionados ao Uso de Cocaína / Ventrículos do Coração / Hipertensão Pulmonar Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Artéria Pulmonar / Ecocardiografia Doppler / Pressão Propulsora Pulmonar / Cocaína / Transtornos Relacionados ao Uso de Cocaína / Ventrículos do Coração / Hipertensão Pulmonar Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article