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Interferon Chemokine Score and Other Cytokine Measures Track With Changes in Disease Activity in Patients With Juvenile and Adult Dermatomyositis.
Crowson, Cynthia S; Hein, Molly S; Pendegraft, Richard S; Strausbauch, Michael A; Niewold, Timothy B; Ernste, Floranne C; Dvergsten, Jeffrey; Amin, Shreyasee; Wampler Muskardin, Theresa L; Peterson, Erik; Baechler, Emily C; Reed, Ann M.
Afiliação
  • Crowson CS; Mayo Clinic College of Medicine Rochester Minnesota.
  • Hein MS; Mayo Clinic College of Medicine Rochester Minnesota.
  • Pendegraft RS; Mayo Clinic College of Medicine Rochester Minnesota.
  • Strausbauch MA; Mayo Clinic College of Medicine Rochester Minnesota.
  • Niewold TB; New York University Medical Center Durham North Carolina.
  • Ernste FC; Mayo Clinic College of Medicine Rochester Minnesota.
  • Dvergsten J; Duke University Durham North Carolina.
  • Amin S; Mayo Clinic College of Medicine Rochester Minnesota.
  • Wampler Muskardin TL; New York University Medical Center Durham North Carolina.
  • Peterson E; University of Minnesota Minneapolis.
  • Baechler EC; University of Minnesota Minneapolis.
  • Reed AM; Duke University Durham North Carolina.
ACR Open Rheumatol ; 1(2): 83-89, 2019 Apr.
Article em En | MEDLINE | ID: mdl-31777784
ABSTRACT

OBJECTIVE:

Our aim was to identify cytokines and chemokines in patients with adult dermatomyositis (DM) and juvenile dermatomyositis (JDM) that predict changes in disease activity.

METHODS:

Multiplexed immunoassays (Meso Scale Discovery) enabled simultaneous measurement of interferon (IFN)-regulated chemokines and other pro- and anti-inflammatory cytokines specific to differentiation of specific T-cell and innate pathways. Cytokine scores were computed for IFNCK (IP-10, MCP-1), Th1 (IFNÉ£, TNFα, and IL2), Th2 (IL4, IL10, IL12, and IL 13), Th17 (IL6, IL17, IL1ß), macrophage (MIP-1α, MIP-1ß, IL8), and regulatory (IL10, TNFα) factors. Spearman correlation and mixed models were used to examine whether cytokines at a previous visit predict change in disease activity at the next visit.

RESULTS:

The study included 36 patients (16 DM and 20 JDM) with at least two visits (87 patient intervals between two visits). Mean age (SD) at inclusion was 56.9 (18.4) years for DM and 10.8 (6.6) years in JDM, 67% of patients were female, 89% Caucasian. The mean (SD) physician global, muscle and extra-muscular disease activity Visual Analog Scale scores at inclusion were 41 (26), 36 (30), and 34 (21) mm, respectively. The change in IFN score from one visit to the next was associated with the change in physician global (P = 0.010) and extramuscular (P < 0.001) disease activity scores. Preliminary results revealed significant correlations of previous IFNCK score and IL-6 with subsequent disease activity measures, but after adjustment for multiple visits per patient, these associations did not reach statistical significance.

CONCLUSION:

There is a potential relationship between IFNCK and other cytokine scores seen in adult and juvenile DM with future disease states.

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2019 Tipo de documento: Article