Treating periodontal disease in patients with myocardial infarction: A randomized clinical trial.
Eur J Intern Med
; 71: 76-80, 2020 01.
Article
em En
| MEDLINE
| ID: mdl-31810741
ABSTRACT
BACKGROUND:
Periodontitis has been associated with coronary artery disease, but the impact of a periodontal treatment on the endothelial function of patients with a recent ST-segment elevation myocardial infarction (STEMI) was not investigated.METHODS:
Randomized controlled trial (NCT02543502). Patients admitted between August 2012 and January 2015 were included. Patients were screened during the index hospitalization for STEMI, and those with severe periodontal disease were randomized 2â¯weeks later to periodontal treatment or to control. The primary endpoint of this trial was the between group difference in the variation of flow-mediated vasodilation (FMD) in the brachial artery assessed by ultrasound from baseline to the 6-month follow-up. Secondary outcomes were cardiovascular events, adverse effects of periodontal treatment and inflammatory markers.RESULTS:
Baseline characteristics were balanced between patients in the intervention (nâ¯=â¯24) and control groups (nâ¯=â¯24). There was a significant FMD improvement in the intervention group (3.05%; pâ¯=â¯.01), but not in the control group (-0.29%; pâ¯=â¯.79) (pâ¯=â¯.03 for the intergroup comparison). Periodontal treatment was not associated with any adverse events and the inflammatory profile and cardiovascular events were not significantly different between both groups.CONCLUSIONS:
Treatment of periodontal disease improves the endothelial function of patients with a recent myocardial infarction, without adverse clinical events. Larger trials are needed to assess the benefit of periodontal treatment on clinical outcomes. CLINICAL TRIAL REGISTRATION NCT02543502 (https//clinicaltrials.gov/ct2/show/NCT02543502?term=NCT02543502&rank=1).Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Doenças Periodontais
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Doença da Artéria Coronariana
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Intervenção Coronária Percutânea
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Infarto do Miocárdio com Supradesnível do Segmento ST
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Infarto do Miocárdio
Tipo de estudo:
Clinical_trials
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article