Single-pulse transcranial magnetic stimulation in amyotrophic lateral sclerosis.
Muscle Nerve
; 61(3): 330-337, 2020 03.
Article
em En
| MEDLINE
| ID: mdl-31837153
ABSTRACT
INTRODUCTION:
Transcranial magnetic stimulation (TMS) is one of the best methods to identify changes in the corticospinal tract. We used single-pulse TMS at the beginning of the disease and in the follow-up in a group of patients with amyotrophic lateral sclerosis (ALS).METHODS:
We evaluated the corticospinal tract in the bulbar, upper, and lower regions in 55 patients with ALS, and we monitored them for a period of 24 months. Data were correlated with clinical scales.RESULTS:
An increase of central motor conduction time (CMCT) was the most sensitive marker of upper motor neuron involvement. The resting motor threshold, CMCT, and the central silent period increased linearly with disease duration and upper/lower motor neuron involvement.DISCUSSION:
Transcranial magnetic stimulation could be an essential neurophysiological technique in the early phase of ALS because it has been shown to be useful in detecting subclinical upper motor neuron involvement. Multiple evaluations of several regions increase TMS sensitivity.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tratos Piramidais
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Estimulação Magnética Transcraniana
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Esclerose Lateral Amiotrófica
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Neurônios Motores
Tipo de estudo:
Prognostic_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article