Histopathologic findings characteristic of CARD14-associated papulosquamous eruption.
J Cutan Pathol
; 47(5): 425-430, 2020 May.
Article
em En
| MEDLINE
| ID: mdl-31849081
ABSTRACT
BACKGROUND:
Pathogenic mutations in caspase recruitment domain-containing protein 14 (CARD14) lead to CARD14-associated papulosquamous eruption, which shares clinicopathologic findings with psoriasis and pityriasis rubra pilaris. We aimed to describe distinguishing histopathologic features of CARD14-associated papulosquamous eruption.METHODS:
This retrospective study examined the histopathologic features of specimens from patients with confirmed CARD14-associated papulosquamous eruption and adult patients with plaque psoriasis and pityriasis rubra pilaris.RESULTS:
Lesional skin biopsies from patients with CARD14-associated papulosquamous eruption consistently showed alternating checkerboard parakeratosis and orthokeratosis, acanthosis without acantholysis, and dilated vessels in the dermal papillae, with some cases also showing follicular plugging.CONCLUSION:
CARD14-associated papulosquamous eruption has a range of findings, with a predominance of features typically associated with pityriasis rubra pilaris.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pitiríase Rubra Pilar
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Psoríase
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Dermatopatias Papuloescamosas
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Proteínas Adaptadoras de Sinalização CARD
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Guanilato Ciclase
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Proteínas de Membrana
Tipo de estudo:
Diagnostic_studies
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Observational_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Humans
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Middle aged
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article