Solubility and Bioavailability Enhancement of Oridonin: A Review.
Molecules
; 25(2)2020 Jan 14.
Article
em En
| MEDLINE
| ID: mdl-31947574
ABSTRACT
Oridonin (ORI), an ent-kaurene tetracyclic diterpenoid compound, is isolated from Chinese herb Rabdosia rubescens with various biological and pharmacological activities including anti-tumor, anti-microbial and anti-inflammatory effects. However, the clinical application of ORI is limited due to its low solubility and poor bioavailability. In order to overcome these shortcomings, many strategies have been explored such as structural modification, new dosage form, etc. This review provides a detailed discussion on the research progress to increase the solubility and bioavailability of ORI.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Diterpenos do Tipo Caurano
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Anti-Inflamatórios
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Antineoplásicos Fitogênicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article