A membrane-tethering pepducin derived from formyl peptide receptor 3 shows strong therapeutic effects against sepsis.

Lee, Ha Young; Kim, Hyung Sik; Jeong, Yu Sun; Kim, Ji Cheol; Bae, Yong-Soo; Jo, You Hwan; Park, Joon Seong; Bae, Yoe-Sik

Lee, Ha Young; Kim, Hyung Sik; Jeong, Yu Sun; Kim, Ji Cheol; Bae, Yong-Soo; Jo, You Hwan; Park, Joon Seong; Bae, Yoe-Sik.

Afiliação

Lee HY; Department of Biological Sciences, Sungkyunkwan University, Suwon, 16419, Republic of Korea. Electronic address: hayoung@skku.edu.
Kim HS; Department of Biological Sciences, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
Jeong YS; Department of Biological Sciences, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
Kim JC; Department of Biological Sciences, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
Bae YS; Department of Biological Sciences, Sungkyunkwan University, Suwon, 16419, Republic of Korea; Science Research Center (SRC) for Immune Research on Non-Lymphoid Organ (CIRNO), Sungkyunkwan University, Suwon, 16419, Republic of Korea.
Jo YH; Department of Emergency Medicine, Seoul National University Bundang Hospital, Seongnam, 13620, Republic of Korea.
Park JS; Department of Hematology-Oncology, Ajou University School of Medicine, Suwon, 16499, Republic of Korea.
Bae YS; Department of Biological Sciences, Sungkyunkwan University, Suwon, 16419, Republic of Korea; Science Research Center (SRC) for Immune Research on Non-Lymphoid Organ (CIRNO), Sungkyunkwan University, Suwon, 16419, Republic of Korea. Electronic address: yoesik@skku.edu.

Biochem Biophys Res Commun ; 524(1): 156-162, 2020 03 26.

Article em En | MEDLINE | ID: mdl-31982133

Assuntos

Membrana Celular/metabolismo; Lipopeptídeos/uso terapêutico; Receptores de Formil Peptídeo/metabolismo; Sepse/tratamento farmacológico; Animais; Ceco/patologia; Membrana Celular/efeitos dos fármacos; Citocinas/biossíntese; Células HEK293; Humanos; Mediadores da Inflamação/metabolismo; Ligadura; Lipopeptídeos/administração & dosagem; Lipopeptídeos/farmacologia; Masculino; Camundongos Endogâmicos C57BL; Neutrófilos/metabolismo; Punções; Sepse/patologia

Palavras-chave

Formyl peptide receptor 3; Neutrophil; Pepducin; Sepsis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Membrana Celular / Sepse / Receptores de Formil Peptídeo / Lipopeptídeos Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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