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Reciprocal Regulation of HSD11B1 and HSD11B2 Predicts Glucocorticoid Sensitivity in Childhood Acute Lymphoblastic Leukemia.
Sai, Shuji; Esteves, Cristina; Kelly, Val; Sakaguchi, Kimiyoshi; McAndrew, Rachel; Chudleigh, Sandra; Spence, Alison; Gibson, Brenda; Thomas, Angela; Chapman, Karen E.
Afiliação
  • Sai S; Center for Cardiovascular Science, The Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, UK; Department of Pediatrics, Hamamatsu University School of Medicine, Hamamatsu, Japan; Department of Pediatrics, Teine-Keijinkai Hospital, Sapporo, Japan. Electronic address: shuji-sa
  • Esteves C; Center for Cardiovascular Science, The Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, UK; Division of Developmental Biology, The Roslin Institute, The University of Edinburgh, Edinburgh, UK.
  • Kelly V; Center for Cardiovascular Science, The Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, UK.
  • Sakaguchi K; Department of Pediatrics, Hamamatsu University School of Medicine, Hamamatsu, Japan.
  • McAndrew R; Department of Pediatric Hematology, Royal Hospital for Sick Children, Edinburgh, UK.
  • Chudleigh S; Department of Pediatric Hematology, Royal Hospital for Sick Children, Yorkhill, Glasgow, UK.
  • Spence A; Department of Pediatric Hematology, Royal Hospital for Sick Children, Yorkhill, Glasgow, UK.
  • Gibson B; Department of Pediatric Hematology, Royal Hospital for Sick Children, Yorkhill, Glasgow, UK.
  • Thomas A; Department of Pediatric Hematology, Royal Hospital for Sick Children, Edinburgh, UK.
  • Chapman KE; Center for Cardiovascular Science, The Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, UK.
J Pediatr ; 220: 249-253, 2020 05.
Article em En | MEDLINE | ID: mdl-31987650
ABSTRACT
There are few biomarkers to predict efficacy of glucocorticoid treatment in childhood acute lymphoblastic leukemia (ALL) at diagnosis. Here, we demonstrate reciprocal regulation of 11beta-hydroxysteroid dehydrogenase (11ß-HSD), may predict the apoptotic response of ALL to glucocorticoid treatment. Our data may be useful to refine glucocorticoid treatment, to retain benefit while minimizing side effects.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dexametasona / Prednisolona / 11-beta-Hidroxiesteroide Desidrogenase Tipo 1 / 11-beta-Hidroxiesteroide Desidrogenase Tipo 2 / Leucemia-Linfoma Linfoblástico de Células Precursoras / Glucocorticoides Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dexametasona / Prednisolona / 11-beta-Hidroxiesteroide Desidrogenase Tipo 1 / 11-beta-Hidroxiesteroide Desidrogenase Tipo 2 / Leucemia-Linfoma Linfoblástico de Células Precursoras / Glucocorticoides Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article