Lanthanide-Doped SPIONs Bioconjugation with Trastuzumab for Potential Multimodal Anticancer Activity and Magnetic Hyperthermia.
Nanomaterials (Basel)
; 10(2)2020 Feb 08.
Article
em En
| MEDLINE
| ID: mdl-32046284
ABSTRACT
Iron oxide-based nanoparticles have been modified in their core with holmium(III) in an amount affecting only slightly their magnetic properties. Nanoparticles were conjugated covalently with biomolecule of trastuzumab (Herceptin®), the monoclonal antibody that recognizes cancer cells overexpressing HER2 receptors targeting such nanoparticles to the specified tumor tissues. Systematic studies of Ho3+-doped bioconjugates were carried out as a preliminary step for future replacement of 'cold' Ho with 166Ho radionuclide, emitting 'soft' beta(-) radiation for possible targeted radionuclide therapy. Physicochemical properties of the obtained bioconjugates were subsequently tested for use in magnetic hyperthermia, considered as an effective, low-invasiveness anticancer therapy. With such a system we expect to achieve both active targeting and multimodal action by simultaneous internal and localized irradiation and magnetic hyperthermia of specific cancers.
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MEDLINE
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En
Ano de publicação:
2020
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Article