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Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region.
Schlepckow, Kai; Monroe, Kathryn M; Kleinberger, Gernot; Cantuti-Castelvetri, Ludovico; Parhizkar, Samira; Xia, Dan; Willem, Michael; Werner, Georg; Pettkus, Nadine; Brunner, Bettina; Sülzen, Alice; Nuscher, Brigitte; Hampel, Heike; Xiang, Xianyuan; Feederle, Regina; Tahirovic, Sabina; Park, Joshua I; Prorok, Rachel; Mahon, Cathal; Liang, Chun-Chi; Shi, Ju; Kim, Do Jin; Sabelström, Hanna; Huang, Fen; Di Paolo, Gilbert; Simons, Mikael; Lewcock, Joseph W; Haass, Christian.
Afiliação
  • Schlepckow K; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.
  • Monroe KM; Denali Therapeutics Inc., South San Francisco, CA, USA.
  • Kleinberger G; Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.
  • Cantuti-Castelvetri L; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.
  • Parhizkar S; Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.
  • Xia D; Denali Therapeutics Inc., South San Francisco, CA, USA.
  • Willem M; Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.
  • Werner G; Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.
  • Pettkus N; Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.
  • Brunner B; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.
  • Sülzen A; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.
  • Nuscher B; Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.
  • Hampel H; Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.
  • Xiang X; Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.
  • Feederle R; Graduate School of Systemic Neuroscience, Ludwig-Maximilians-Universität München, Munich, Germany.
  • Tahirovic S; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.
  • Park JI; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
  • Prorok R; Helmholtz Center Munich, German Research Center for Environmental Health, Institute for Diabetes and Obesity, Core Facility Monoclonal Antibody Development, Munich, Germany.
  • Mahon C; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.
  • Liang CC; Denali Therapeutics Inc., South San Francisco, CA, USA.
  • Shi J; Denali Therapeutics Inc., South San Francisco, CA, USA.
  • Kim DJ; Denali Therapeutics Inc., South San Francisco, CA, USA.
  • Sabelström H; Denali Therapeutics Inc., South San Francisco, CA, USA.
  • Huang F; Denali Therapeutics Inc., South San Francisco, CA, USA.
  • Di Paolo G; Denali Therapeutics Inc., South San Francisco, CA, USA.
  • Simons M; Denali Therapeutics Inc., South San Francisco, CA, USA.
  • Lewcock JW; Denali Therapeutics Inc., South San Francisco, CA, USA.
  • Haass C; Denali Therapeutics Inc., South San Francisco, CA, USA.
EMBO Mol Med ; 12(4): e11227, 2020 04 07.
Article em En | MEDLINE | ID: mdl-32154671
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glicoproteínas de Membrana / Receptores Imunológicos / Microglia / Anticorpos Monoclonais / Mieloma Múltiplo Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glicoproteínas de Membrana / Receptores Imunológicos / Microglia / Anticorpos Monoclonais / Mieloma Múltiplo Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article