Heterogeneous Nuclear Ribonucleoprotein L Negatively Regulates Foot-and-Mouth Disease Virus Replication through Inhibition of Viral RNA Synthesis by Interacting with the Internal Ribosome Entry Site in the 5' Untranslated Region.

Sun, Chao; Liu, Mengmeng; Chang, Jitao; Yang, Decheng; Zhao, Bo; Wang, Haiwei; Zhou, Guohui; Weng, Changjiang; Yu, Li

Sun, Chao; Liu, Mengmeng; Chang, Jitao; Yang, Decheng; Zhao, Bo; Wang, Haiwei; Zhou, Guohui; Weng, Changjiang; Yu, Li.

Afiliação

Sun C; Division of Livestock Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.
Liu M; Division of Livestock Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.
Chang J; Division of Livestock Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.
Yang D; Division of Livestock Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China yangdecheng@caas.cn yuli02@caas.cn.
Zhao B; Division of Livestock Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.
Wang H; Division of Livestock Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.
Zhou G; Division of Livestock Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.
Weng C; Division of Veterinary Fundamental Immunology, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.
Yu L; Division of Livestock Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China yangdecheng@caas.cn yuli02@caas.cn.

J Virol ; 94(10)2020 05 04.

Article em En | MEDLINE | ID: mdl-32161169

Assuntos

Regiões 5' não Traduzidas; Vírus da Febre Aftosa/fisiologia; Ribonucleoproteínas Nucleares Heterogêneas Grupo L/metabolismo; Sítios Internos de Entrada Ribossomal/fisiologia; RNA Viral/biossíntese; Replicação Viral/fisiologia; Animais; Linhagem Celular; Vírus da Febre Aftosa/genética; Regulação Viral da Expressão Gênica; Técnicas de Inativação de Genes; Células HEK293; Ribonucleoproteínas Nucleares Heterogêneas Grupo L/genética; Interações entre Hospedeiro e Microrganismos/fisiologia; Humanos; Imunoprecipitação; Ligação Proteica; RNA Viral/genética; Transcriptoma

Palavras-chave

3Dpol; foot-and-mouth disease virus; heterogeneous nuclear ribonucleoprotein L; internal ribosome entry site; viral RNA synthesis; virus-host interaction

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Replicação Viral / RNA Viral / Regiões 5' não Traduzidas / Vírus da Febre Aftosa / Ribonucleoproteínas Nucleares Heterogêneas Grupo L / Sítios Internos de Entrada Ribossomal Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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